Evidence map›Paper›PMID 20305727›Full record

ArticleInternational journal of clinical rheumatology2010

Management of cardiovascular complications in systemic lupus erythematosus.

Carly Skamra, Rosalind Ramsey-Goldman

Registry-linked trialAbstract read
In one paragraph

Article in International journal of clinical rheumatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04046172 (Treatment of Periodontal Disease in Systemic Lupus Erytematosus), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04046172 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Treatment of Periodontal Disease in Systemic Lupus Erytematosus: A Pilot Randomized Controlled Clinical Trial

TypeinterventionalSponsorUniversity College, LondonRan2021 to 2023Enrolled200ConditionsSystemic Lupus Erythematosus, PeriodontitisArmssupra/sub gingival root surface debridement, supra-gingival scaling and polishing
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Observational
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Carly Skamra
Rosalind Ramsey-Goldman

Funding

POSTDOCTORAL RHEUMATOLOGY TRAININGT32AR007611 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PERLMAN, HARRIS R · 2001 to 2022
$4.4M
SUPERANTIGEN INTERACTIONS WITH MHC CLASS II ANTIGENSP60AR030692 · NIAMS · NORTHWESTERN UNIVERSITY · PI RYMER, WILLIAM ZEV · 1986 to 2001
$2.1M
PATIENT-ORIENTED RESEARCH: SYSTEMIC LUPUS ERYTHEMATOSUSK24AR002138 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAMSEY-GOLDMAN, ROSALIND · 2000 to 2009
$1.0M
NIAMS NIH HHS K24 AR002138NIAMS NIH HHS P60 AR030692NIAMS NIH HHS T32 AR007611
6 · The paper itself

Abstract

Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Patients with SLE have an excess risk compared with the general population; this is particularly pronounced in younger women with SLE who have an excess risk of over 50-fold compared with population controls. There is a higher prevalence of subclinical atherosclerosis in patients with SLE compared with controls, as demonstrated by a variety of imaging modalities discussed in this review. The causality of the excess risk of CVD and subclinical atherosclerosis is multifactorial in patients with SLE. While traditional risk factors play a role, after controlling for the traditional Framingham risk factors, the excess risk is still 7.5-fold greater than the general population. This review will also cover novel cardiovascular risk factors and some SLE-specific variables that contribute to CVD risk. This review discusses the risk factor modification and the evidence available for treatment of these risk factors in SLE. There have not yet been any published randomized, controlled trials in patients with SLE with respect to CVD risk factor modifications. Thus, the treatment and management recommendations are based largely on published guidelines for other populations at high risk for CVD.

Identifiers

PMID20305727
PMCPMC2839248

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.