ArticlePLoS biology2010
Spatial epigenetic control of mono- and bistable gene expression.
Article in PLoS biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
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- Tuning up Transcription Factors for Therapy.Molecules (Basel, Switzerland) · 2020Review
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- Multiplexed gene control reveals rapid mRNA turnover.Science advances · 2017Article
- The epigenome: the next substrate for engineering.Genome biology · 2016Review
- Enzyme Sequestration as a Tuning Point in Controlling Response Dynamics of Signalling Networks.PLoS computational biology · 2016Article
- From invasion to latency: intracellular noise and cell motility as key controls of the competition between resource-limited cellular populations.Journal of mathematical biology · 2016Article
- Quantification of pre-mRNA escape rate and synergy in splicing.Nucleic acids research · 2014Article
- Breaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing.PloS one · 2014Article
- Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts.BMC biology · 2013Article
- The role of multiple marks in epigenetic silencing and the emergence of a stable bivalent chromatin state.PLoS computational biology · 2013Article
- Article
- Engineering microbial systems to explore ecological and evolutionary dynamics.Current opinion in biotechnology · 2012Review
- Stochastic signalling rewires the interaction map of a multiple feedback network during yeast evolution.Nature communications · 2012Article
- Bistability in feedback circuits as a byproduct of evolution of evolvability.Molecular systems biology · 2012Article
- A canonical model of multistability and scale-invariance in biological systems.PLoS computational biology · 2012Article
- Article
- Modeling of chromosomal epigenetic silencing processes.Transcription · 2011Article
- Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size.Biophysical journal · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bistability in signaling networks is frequently employed to promote stochastic switch-like transitions between cellular differentiation states. Differentiation can also be triggered by antagonism of activators and repressors mediated by epigenetic processes that constitute regulatory circuits anchored to the chromosome. Their regulatory logic has remained unclear. A reaction-diffusion model reveals that the same reaction mechanism can support both graded monostable and switch-like bistable gene expression, depending on whether recruited repressor proteins generate a single silencing gradient or two interacting gradients that flank a gene. Our experiments confirm that chromosomal recruitment of activator and repressor proteins permits a plastic form of control; the stability of gene expression is determined by the spatial distribution of silencing nucleation sites along the chromosome. The unveiled regulatory principles will help to understand the mechanisms of variegated gene expression, to design synthetic genetic networks that combine transcriptional regulatory motifs with chromatin-based epigenetic effects, and to control cellular differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.