SynthesisOncogene2010
Meta-analysis of adrenocortical tumour genomics data: novel pathogenic pathways revealed.
Synthesis in Oncogene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A data similarity-based strategy for meta-analysis of transcriptional profiles in cancer.PloS one · 2013Pooled it
- Review
- Plant Natural Compounds in the Treatment of Adrenocortical Tumors.International journal of endocrinology · 2021Review
- A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence.British journal of cancer · 2020Article
- Apoptosis regulation in adrenocortical carcinoma.Endocrine connections · 2019Review
- Screening and Identification of Potential Prognostic Biomarkers in Adrenocortical Carcinoma.Frontiers in genetics · 2019Article
- Identification of Five Genes as a Potential Biomarker for Predicting Progress and Prognosis in Adrenocortical Carcinoma.Journal of Cancer · 2018Article
- Vitamin A, endocrine tissues and hormones: interplay and interactions.Endocrine connections · 2017Article
- 5th International ACC Symposium: Classification of Adrenocortical Cancers from Pathology to Integrated Genomics: Real Advances or Lost in Translation?Hormones & cancer · 2016Review
- Article
- Cell cycle dependent RRM2 may serve as proliferation marker and pharmaceutical target in adrenocortical cancer.American journal of cancer research · 2016Article
- Network analysis reveals potential markers for pediatric adrenocortical carcinoma.OncoTargets and therapy · 2016Article
- MicroRNAs in adrenal tumors: relevance for pathogenesis, diagnosis, and therapy.Cellular and molecular life sciences : CMLS · 2015Review
- Evaluation of 9-cis retinoic acid and mitotane as antitumoral agents in an adrenocortical xenograft model.American journal of cancer research · 2015Article
- The 'omics' of adrenocortical tumours for personalized medicine.Nature reviews. Endocrinology · 2014Review
- Antitumoral effects of 9-cis retinoic acid in adrenocortical cancer.Cellular and molecular life sciences : CMLS · 2014Article
- In silico analysis of pathways affected by differentially expressed microRNA in adrenocortical tumors.Journal of endocrinological investigation · 2013Article
- Minireview: miRomics in endocrinology: a novel approach for modeling endocrine diseases.Molecular endocrinology (Baltimore, Md.) · 2013Review
- Single nucleotide polymorphism array profiling of adrenocortical tumors--evidence for an adenoma carcinoma sequence?PloS one · 2013Article
- Vitamin D receptor, an important transcription factor associated with aldosterone-producing adenoma.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sporadic adrenocortical tumours are common, but their pathogenesis is poorly elucidated. In this study, we present a meta-analysis and review of gene expression microarray and comparative genome hybridization (CGH) studies performed to date on these tumours, including our own data. Data of whole genome microarray studies from altogether 164 tumours (97 benign, 67 malignant) and 18 normal tissues were reclassified and reanalysed. Significant gene sets and cytogenetic changes from publications without available genomic data were also examined including 269 benign, 215 malignant tumour and 30 normal tissues. In our experimental study, 11 tumour and four normal samples were analysed by parallel mRNA and CGH profiling. Data were examined by an integrative bioinformatics approach (GeneSpring, Gene Set Enrichment Analysis and Ingenuity Pathway Analysis softwares) searching for common gene expression changes and paralleling chromosome aberrations. Both meta-analysis of available mRNA and CGH profiling data and our experimental study revealed three major pathogenetic pathways: (1) cell cycle, (2) retinoic acid signalling (including lipopolysaccharide/Toll like receptor 4 pathway), (3) complement system and antigen presentation. These pathways include novel, previously undescribed pathomechanisms of adrenocortical tumours, and associated gene products may serve as diagnostic markers of malignancy and therapeutic targets.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.