ArticleOncogene2010
A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis.
Article in Oncogene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- MDM2 inhibitors in cancer immunotherapy: Current status and perspective.Genes & diseases · 2024Review
- Characterization of anCancers · 2023Article
- Review
- Review
- The Role of MTBP as a Replication Origin Firing Factor.Biology · 2022Review
- MTBP enhances the activation of transcription factor ETS-1 and promotes the proliferation of hepatocellular carcinoma cells.Frontiers in oncology · 2022Article
- The role of DDK and Treslin-MTBP in coordinating replication licensing and pre-initiation complex formation.Open biology · 2021Article
- MTBP phosphorylation controls DNA replication origin firing.Scientific reports · 2021Article
- MTBP promoted the proliferation, migration and invasion of colon cancer cells by activating the expression of ZEB2.Animal cells and systems · 2021Article
- Mouse Models ofFrontiers in immunology · 2020Review
- MTBP regulates cell survival and therapeutic sensitivity in TP53 wildtype glioblastomas.Theranostics · 2019Article
- Article
- MTBP promotes migration and invasion by regulation of ZEB2-mediated epithelial-mesenchymal transition in lung cancer cells.OncoTargets and therapy · 2018Article
- Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice.Aging · 2016Article
- Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis.Hepatoma research · 2016Article
- MTBP Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Enhancing the MDM2-Mediated Degradation of E-Cadherin.Digestive diseases and sciences · 2015Article
- MTBP inhibits migration and metastasis of hepatocellular carcinoma.Clinical & experimental metastasis · 2015Article
- MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival.Molecular cancer research : MCR · 2014Article
- Oncogenic protein MTBP interacts with MYC to promote tumorigenesis.Cancer research · 2014Article
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Mdm2 binding protein (MTBP) has been implicated in cell-cycle arrest and the Mdm2/p53 tumor suppressor pathway through its interaction with Mdm2. To determine the function of MTBP in tumorigenesis and its potential role in the Mdm2/p53 pathway, we crossed Mtbp-deficient mice to Emu-myc transgenic mice, in which overexpression of the oncogene c-Myc induces B-cell lymphomas primarily through inactivation of the Mdm2/p53 pathway. We report that Myc-induced B-cell lymphoma development in Mtbp heterozygous mice was profoundly delayed. Surprisingly, reduced levels of Mtbp did not lead to an increase in B-cell apoptosis or affect Mdm2. Instead, an Mtbp deficiency inhibited Myc-induced proliferation and the upregulation of Myc target genes necessary for cell growth. Consistent with a role in proliferation, Mtbp expression was induced by Myc and other factors that promote cell-cycle progression and was elevated in lymphomas from humans and mice. Therefore, Mtbp functioned independent of Mdm2 and was a limiting factor for the proliferative and transforming functions of Myc. Thus, Mtbp is a previously unrecognized regulator of Myc-induced tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.