ArticleNature genetics2010
Rare genetic variation at Zea mays crtRB1 increases beta-carotene in maize grain.
Article in Nature genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers.
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Who cites it
174 citing papers in PubMed, 476 citations in OpenAlex.
- Yellow maize with high β-carotene is an effective source of vitamin A in healthy Zimbabwean men.The American journal of clinical nutrition · 2011Trial
- Translating functional molecular knowledge into crop-breeding success.Nature reviews. Genetics · 2026Review
- Integrated metabolomics and microbiome analyses reveal nutritional differences between yellow and white maize (Food chemistry: X · 2026Article
- Genetic Dissection and Functional Validation ofInternational journal of molecular sciences · 2026Article
- Stearoyl-CoA Desaturase (SCD) Gene Based Molecular Breeding Enhances Nutritional Quality and Growth Performance in the Oyster (Crassostrea angulata).Marine biotechnology (New York, N.Y.) · 2026Article
- Review
- Advancing provitamin A biofortification in sorghum: from allele mining and marker development to prebreeding and breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Genetic Dissection of Carotenoid Variation by Integrating Quantitative Trait Loci Mapping and Candidate Region Association Study in Sweet Corn.Plants (Basel, Switzerland) · 2025Article
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- ORANGE family proteins: multifunctional chaperones shaping plant carotenoid level, plastid development, stress tolerance, and more.Molecular horticulture · 2025Review
- Enrichment of Vitamin A and Vitamin E in Sweet Corn Kernels Through Genomics-Assisted Introgression of Mutant Version of crtRB1 and vte4 Genes.Applied biochemistry and biotechnology · 2025Article
- Analysis of nutritional composition in opaque2- and crtRB1-based single- and double-biofortified super sweet corn.Journal of applied genetics · 2025Article
- Genomics-assisted stacking of waxy1, opaque2, and crtRB1 genes for enhancing amylopectin in biofortified maize for industrial utilization and nutritional security.Functional & integrative genomics · 2025Article
- Development and Validation of Multiplex-PCR Assay forPlants (Basel, Switzerland) · 2025Article
- miR827 orchestrates the regulation of SPX-MFS1 and SPX-MFS5 with the assistance of lncRNA767 to enhance phosphate starvation tolerance and maize development.Plant biotechnology journal · 2024Article
- A Critical Review of Recent Advances in Maize Stress Molecular Biology.International journal of molecular sciences · 2024Review
- Investigating genomic prediction strategies for grain carotenoid traits in a tropical/subtropical maize panel.G3 (Bethesda, Md.) · 2024Article
- Understanding grain development in the Poaceae family by comparing conserved and distinctive pathways through omics studies in wheat and maize.Frontiers in plant science · 2024Review
- Enhancement of nutritional quality in maize kernel through marker-assisted breeding for vte4, crtRB1, and opaque2 genes.Journal of applied genetics · 2023Article
- Hybrid performance evaluation and genome-wide association analysis of root system architecture in a maize association population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
114 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breeding to increase beta-carotene levels in cereal grains, termed provitamin A biofortification, is an economical approach to address dietary vitamin A deficiency in the developing world. Experimental evidence from association and linkage populations in maize (Zea mays L.) demonstrate that the gene encoding beta-carotene hydroxylase 1 (crtRB1) underlies a principal quantitative trait locus associated with beta-carotene concentration and conversion in maize kernels. crtRB1 alleles associated with reduced transcript expression correlate with higher beta-carotene concentrations. Genetic variation at crtRB1 also affects hydroxylation efficiency among encoded allozymes, as observed by resultant carotenoid profiles in recombinant expression assays. The most favorable crtRB1 alleles, rare in frequency and unique to temperate germplasm, are being introgressed via inexpensive PCR marker-assisted selection into tropical maize germplasm adapted to developing countries, where it is most needed for human health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.