ArticleCell adhesion & migration
Tropomyosin isoform modulation of focal adhesion structure and cell migration.
Article in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Knockdown of TTC9 inhibits the proliferation, migration and invasion, but induces the apoptosis of lung adenocarcinoma cells.Heliyon · 2022Article
- The association between diabetes and obesity with Dengue infections.Diabetology & metabolic syndrome · 2022Review
- Identification of Hub Genes and Pathways in Gastric Adenocarcinoma Based on Bioinformatics Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Splicing Busts a Move: Isoform Switching Regulates Migration.Trends in cell biology · 2020Review
- Mapping the Mechanome-A Protocol for Simultaneous Live Imaging and Quantitative Analysis of Cell Mechanoadaptation and Ingression.Bio-protocol · 2019Article
- Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa Acquisita.International journal of molecular sciences · 2016Review
- Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton.PloS one · 2015Article
- Movers and shakers: cell cytoskeleton in cancer metastasis.British journal of pharmacology · 2014Review
- Tropomyosin Tm5NM1 spatially restricts src kinase activity through perturbation of Rab11 vesicle trafficking.Molecular and cellular biology · 2014Article
- Interplay between the overlapping ends of tropomyosin and the N terminus of cardiac troponin T affects tropomyosin states on actin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover.The Journal of biological chemistry · 2013Article
- An RNAi screen reveals intestinal regulators of branching morphogenesis, differentiation, and stem cell proliferation in planarians.Developmental cell · 2012Article
- N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Tropomyosin isoforms and reagents.Bioarchitecture · 2011Article
- Scared stiff: Stabilizing the actin cytoskeleton to stop invading cancer cells in their tracks.Bioarchitecture · 2011Article
- Interior decoration: tropomyosin in actin dynamics and cell migration.Cell adhesion & migrationReview
- S100A4 downregulates filopodia formation through increased dynamic instability.Cell adhesion & migrationArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orderly cell migration is essential for embryonic development, efficient wound healing and a functioning immune system and the dysregulation of this process leads to a number of pathologies. The speed and direction of cell migration is critically dependent on the structural organization of focal adhesions in the cell. While it is well established that contractile forces derived from the acto-myosin filaments control the structure and growth of focal adhesions, how this may be modulated to give different outcomes for speed and persistence is not well understood. The tropomyosin family of actin-associating proteins are emerging as important modulators of the contractile nature of associated actin filaments. The multiple non-muscle tropomyosin isoforms are differentially expressed between tissues and across development and are thought to be major regulators of actin filament functional specialization. In the present study we have investigated the effects of two splice variant isoforms from the same alpha-tropomyosin gene, TmBr1 and TmBr3, on focal adhesion structure and parameters of cell migration. These isoforms are normally switched on in neuronal cells during differentiation and we find that exogenous expression of the two isoforms in undifferentiated neuronal cells has discrete effects on cell migration parameters. While both isoforms cause reduced focal adhesion size and cell migration speed, they differentially effect actin filament phenotypes and migration persistence. Our data suggests that differential expression of tropomyosin isoforms may coordinate acto-myosin contractility and focal adhesion structure to modulate cell speed and persistence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.