ArticleEukaryotic cell2010
Spatial and developmental differentiation of mannitol dehydrogenase and mannitol-1-phosphate dehydrogenase in Aspergillus niger.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 52 citations in OpenAlex.
- Research progress on heat stress response mechanisms inFrontiers in microbiology · 2026Review
- Study on the metabolic changes and regulatory mechanism ofMicrobiology spectrum · 2024Article
- Compatible solutes determine the heat resistance of conidia.Fungal biology and biotechnology · 2023Article
- Efficient simultaneous production of extracellular polyol esters of fatty acids and intracellular lipids from inulin by a deep-sea yeast Rhodotorula paludigena P4R5.Microbial cell factories · 2019Article
- Blocking hexose entry into glycolysis activates alternative metabolic conversion of these sugars and upregulates pentose metabolism in Aspergillus nidulans.BMC genomics · 2018Article
- The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species.Microbiology and molecular biology reviews : MMBR · 2016Review
- Cytosolic streaming in vegetative mycelium and aerial structures of Aspergillus niger.Studies in mycology · 2013Article
- The effect of natamycin on the transcriptome of conidia of Aspergillus niger.Studies in mycology · 2013Article
- Role of mannitol metabolism in the pathogenicity of the necrotrophic fungus Alternaria brassicicola.Frontiers in plant science · 2013Article
- Substrate cycles in Penicillium chrysogenum quantified by isotopic non-stationary flux analysis.Microbial cell factories · 2012Article
- Development stage-specific proteomic profiling uncovers small, lineage specific proteins most abundant in the Aspergillus Fumigatus conidial proteome.Proteome science · 2012Article
- Expression of biomass-degrading enzymes is a major event during conidium development in Trichoderma reesei.Eukaryotic cell · 2011Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of a mannitol cycle in fungi has been subject to discussion for many years. Recent studies have found no evidence for the presence of this cycle and its putative role in regenerating NADPH. However, all enzymes of the cycle could be measured in cultures of Aspergillus niger. In this study we have analyzed the localization of two enzymes from the pathway, mannitol dehydrogenase and mannitol-1-phosphate dehydrogenase, and the expression of their encoding genes in nonsporulating and sporulating cultures of A. niger. Northern analysis demonstrated that mpdA was expressed in both sporulating and nonsporulating mycelia, while expression of mtdA was expressed only in sporulating mycelium. More detailed studies using green fluorescent protein and dTomato fused to the promoters of mtdA and mpdA, respectively, demonstrated that expression of mpdA occurs in vegetative hyphae while mtdA expression occurs in conidiospores. Activity assays for MtdA and MpdA confirmed the expression data, indicating that streaming of these proteins is not likely to occur. These results confirm the absence of the putative mannitol cycle in A. niger as two of the enzymes of the cycle are not present in the same part of A. niger colonies. The results also demonstrate the existence of spore-specific genes and enzymes in A. niger.
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