ArticleThe Journal of biological chemistry2010
Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
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- HylS', a fragment of truncated hyaluronidase ofVirulence · 2024Article
- A genetic regulatory see-saw of biofilm and virulence in MRSA pathogenesis.Frontiers in microbiology · 2023Review
- CipA mediates complement resistance ofFrontiers in immunology · 2022Article
- Article
- Pathogenicity and virulence ofVirulence · 2021Review
- Complement Inactivation Strategy ofInternational journal of molecular sciences · 2021Article
- Complement Evasion Strategies of Human Pathogenic Bacteria.Indian journal of microbiology · 2020Review
- Immune Evasion byMicrobiology spectrum · 2019Review
- An in vivo reporter assay for sRNA-directed gene control in Gram-positive bacteria: identifying a novel sRNA target in Staphylococcus aureus.Nucleic acids research · 2017Article
- Neutrophils and Immunity: From Bactericidal Action to Being Conquered.Journal of immunology research · 2017Review
- Staphylococcal protein Ecb impairs complement receptor-1 mediated recognition of opsonized bacteria.PloS one · 2017Article
- Novel Evasion Mechanisms of the Classical Complement Pathway.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Mechanisms of Host-Pathogen Protein Complex Formation and Bacterial Immune Evasion of Streptococcus suis Protein Fhb.The Journal of biological chemistry · 2016Article
- Bacterial Toxins as Pathogen Weapons Against Phagocytes.Frontiers in microbiology · 2016Review
- Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes.BMC biology · 2015Article
- Staphylococcal manipulation of host immune responses.Nature reviews. Microbiology · 2015Review
- A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins.The Journal of biological chemistry · 2013Article
- Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The human pathogen Staphylococcus aureus secretes several complement evasion molecules to combat the human immune response. Extracellular complement-binding protein (Ecb) binds to the C3d domain of C3 and thereby blocks C3 convertases of the alternative pathway and C5 convertases via all complement pathways. Inhibition of C5 convertases results in complete inhibition of C5a generation and subsequent neutrophil migration. Here, we show that binding of Ecb to the C3d domain of C3b is crucial for inhibition of C5 convertases. Ecb does not interfere with substrate binding to convertases but prevents formation of an active convertase enzyme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.