ArticleThe Journal of biological chemistry2010
Metabolic and transcriptional responses of glycerolipid pathways to a perturbation of glycerol 3-phosphate metabolism in Arabidopsis.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Metabolomic Analysis of Cassava Cultivars in Response to Sri Lankan Cassava Mosaic Virus Infection by Viruliferous Whiteflies.The plant pathology journal · 2025Article
- Rational design of promoter editing confers multipathogen resistance in rice.Genome biology · 2025Article
- Enhanced Stress Tolerance in Rice Through Overexpression of a Chimeric Glycerol-3-Phosphate Dehydrogenase (OEGD).Plants (Basel, Switzerland) · 2025Article
- Elucidating the biochemical basis ofPlant-environment interactions (Hoboken, N.J.) · 2021Article
- The Adjustment of Membrane Lipid Metabolism Pathways in Maize Roots Under Saline-Alkaline Stress.Frontiers in plant science · 2021Article
- Comparative transcriptome analyses of oleaginousBiotechnology for biofuels · 2018Article
- Two Glycerol-3-Phosphate Dehydrogenases fromPlant physiology · 2017Article
- Biochemical and Transcriptional Regulation of Membrane Lipid Metabolism in Maize Leaves under Low Temperature.Frontiers in plant science · 2017Article
- In silico metabolic network analysis of Arabidopsis leaves.BMC systems biology · 2016Article
- Over-expression of Arabidopsis thaliana SFD1/GLY1, the gene encoding plastid localized glycerol-3-phosphate dehydrogenase, increases plastidic lipid content in transgenic rice plants.Journal of plant research · 2016Article
- Characterization of the Fatty Acid Desaturase Genes in Cucumber: Structure, Phylogeny, and Expression Patterns.PloS one · 2016Article
- Adjustments of lipid pathways in plant adaptation to temperature stress.Plant signaling & behavior · 2016Article
- Genomic Foundation of Starch-to-Lipid Switch in Oleaginous Chlorella spp.Plant physiology · 2015Article
- Genome sequencing of adzuki bean (Vigna angularis) provides insight into high starch and low fat accumulation and domestication.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Understanding the biochemical basis of temperature-induced lipid pathway adjustments in plants.The Plant cell · 2015Article
- The path to triacylglyceride obesity in the sta6 strain of Chlamydomonas reinhardtii.Eukaryotic cell · 2014Article
- Linking gene expression and membrane lipid composition of Arabidopsis.The Plant cell · 2014Article
- Glycerol affects root development through regulation of multiple pathways in Arabidopsis.PloS one · 2014Article
- Metabolic interactions between the Lands cycle and the Kennedy pathway of glycerolipid synthesis in Arabidopsis developing seeds.The Plant cell · 2012Article
- A bifunctional enzyme that has both monoacylglycerol acyltransferase and acyl hydrolase activities.Plant physiology · 2012Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycerolipid synthesis in plants involves two major metabolic pathways compartmentalized in the chloroplasts and cytosol, respectively. Although these two parallel pathways are regulated with considerable flexibility, the factors mediating this process remain unclear. To investigate the influence of glycerol 3-phosphate (Gly-3-P) on the interactions of the glycerolipid pathways, we generated transgenic Arabidopsis lines with a feedback-resistant Gly-3-P dehydrogenase gene (gpsA(FR)) from Escherichia coli. gpsA(FR) was detected in the cytosol, but augmented Gly-3-P levels were observed in the cytosol as well as in chloroplasts. Glycerolipid composition and fatty acid positional distribution analyses revealed an altered fatty acid flux that affected not only the molar ratios of glycerolipid species but also their fatty acid composition. To decipher this complex pathway, a transgenic line was subjected to lipidomic analysis and a global gene-expression survey. The results revealed that changes in Gly-3-P metabolism caused altered expression of a broad array of genes. When viewed from the perspective of glycerolipid metabolism, coherent networks emerged, revealing that many enzymatic components of the glycerolipid pathways operate in a modular manner under the influence of Gly-3-P. Transcript levels of the enzymes involved in the prokaryotic pathway were mostly induced, whereas genes of the eukaryotic pathway enzymes were largely suppressed. Hence, the gene-expression changes were consistent with the detected biochemical phenotype. Our results suggest that Gly-3-P modulates the balance of the two glycerolipid pathways in Arabidopsis by influencing both metabolic flux and gene transcription.
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