SynthesisThe journals of gerontology. Series A, Biological sciences and medical sciences2010
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
Synthesis in The journals of gerontology. Series A, Biological sciences and medical sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 13 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
86 citing papers in PubMed, 13 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- A Prospective Analysis of Genetic Variants Associated with Human Lifespan.G3 (Bethesda, Md.) · 2019Pooled it
- A meta-analysis of genome-wide association studies identifies multiple longevity genes.Nature communications · 2019Pooled it
- Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity.Nature communications · 2017Pooled it
- Limitations and risks of meta-analyses of longevity studies.Mechanisms of ageing and development · 2017Pooled it
- Pooled it
- GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Pooled it
- Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.Human molecular genetics · 2014Pooled it
- Pooled it
- Trans-ethnical shift of the risk genotype in the CETP I405V with longevity: a Chinese case-control study and meta-analysis.PloS one · 2013Pooled it
- A genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci.PloS one · 2012Pooled it
- A genome-wide association study of aging.Neurobiology of aging · 2011Pooled it
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.Aging cell · 2011Pooled it
- Meta-analysis of sex-specific genome-wide association studies.Genetic epidemiology · 2010Pooled it
- Trial
- Trial
- Genetic links between multimorbidity and human aging.GeroScience · 2026Article
- Network-driven discovery of repurposable drugs targeting hallmarks of aging.Nature aging · 2026Article
- Genetic architecture of human aging and longevity: Insights from genome-wide association studies.BMB reports · 2026Review
- Article
- Machine vision-based frailty assessment for genetically diverse mice.GeroScience · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors at 20 institutions in 4 countries.
Funding
Abstract
backgroundGenome-wide association studies (GWAS) may yield insights into longevity.
methodsWe performed a meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955). In a second discovery stage, additional genotyping was conducted in the Leiden Longevity Study cohort and the Danish 1905 cohort.
resultsThere were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached the prespecified significance level of 5 x 10(-8). Of the most significant SNPs, 24 were independent signals, and 16 of these SNPs were successfully genotyped in the second discovery stage, with one association for rs9664222, reaching 6.77 x 10(-7) for the combined meta-analysis of CHARGE and the stage 2 cohorts. The SNP lies in a region near MINPP1 (chromosome 10), a well-conserved gene involved in regulation of cellular proliferation. The minor allele was associated with lower odds of survival past age 90 (odds ratio = 0.82). Associations of interest in a homologue of the longevity assurance gene (LASS3) and PAPPA2 were not strengthened in the second stage.
conclusionSurvival studies of larger size or more extreme or specific phenotypes may support or refine these initial findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.