ReviewTrends in endocrinology and metabolism: TEM2010
Immune surveillance of the maternal/fetal interface: controversies and implications.
Review in Trends in endocrinology and metabolism: TEM, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Endometrial Microbiota and Immune Tolerance in Pregnancy.International journal of molecular sciences · 2023Review
- Single-cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion.Cell proliferation · 2021Article
- The Natural Course ofMicroorganisms · 2021Article
- Pig Pregnancies after Transfer of Allogeneic Embryos Show a Dysregulated Endometrial/Placental Cytokine Balance: A Novel Clue for Embryo Death?Biomolecules · 2020Article
- IL-36 Cytokines: Regulators of Inflammatory Responses and Their Emerging Role in Immunology of Reproduction.International journal of molecular sciences · 2019Review
- Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response.Frontiers in immunology · 2019Article
- Fetal death: an extreme manifestation of maternal anti-fetal rejection.Journal of perinatal medicine · 2017Article
- Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response.Journal of perinatal medicine · 2016Article
- Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia.Journal of pathology and translational medicine · 2015Review
- Article
- In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy.PloS one · 2014Article
- Physiological and molecular determinants of embryo implantation.Molecular aspects of medicine · 2013Review
- From mice to women: the conundrum of immunity to infection during pregnancy.Journal of reproductive immunology · 2013Review
- Mechanisms of T cell tolerance towards the allogeneic fetus.Nature reviews. Immunology · 2013Review
- Natural selection in utero induced by mass layoffs: the hCG evidence.Evolutionary applications · 2012Article
- Placenta suppresses experimental autoimmune hypophysitis through soluble TNF receptor 1.Journal of autoimmunity · 2012Article
- Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity.Frontiers in immunology · 2012Article
- Psychoneuroimmunology in pregnancy: immune pathways linking stress with maternal health, adverse birth outcomes, and fetal development.Neuroscience and biobehavioral reviews · 2012Article
- Dendritic cell function at the maternal-fetal interface.Expert review of clinical immunology · 2011Article
- Hormonal evidence supports the theory of selection in utero.American journal of human biology : the official journal of the Human Biology CouncilArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
How the fetal 'allograft' avoids rejection during pregnancy remains a major unresolved immunological paradox. Recent work has suggested that fetomaternal tolerance is in fact maintained by a number of redundant mechanisms, but their relative importance has remained poorly defined. In this paper, I discuss an emerging controversy regarding the ability of maternal T cells to mediate fetal rejection at a time when they appear to be ignorant of fetal and placental antigens. This paradox within a paradox highlights two major research directions in the field of reproductive immunology that, when ultimately reconciled, promise to give significant insight into mechanisms of impaired fertility and compromised fetal and maternal health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.