ArticleThe Journal of pediatrics2010
The role of European genetic admixture in the etiology of the insulin resistance syndrome in children: are the effects mediated by fat accumulation?
Article in The Journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- A critical examination of the relationship between cardiovascular health, cognition, and dementia risk.Journal of Alzheimer's disease : JAD · 2025Article
- Obstructive Sleep Apnea and Alzheimer's Disease Pathology: Is Sleep Architecture the Missing Key?Journal of Alzheimer's disease : JAD · 2024Review
- Association of Promoter Methylation and Expression of Inflammatory Genes IL-6 and TNF-α with the Risk of Coronary Artery Disease in Diabetic and Obese Subjects among Asian Indians.Indian journal of clinical biochemistry : IJCB · 2022Article
- Influence of LRP5 (rs556442) polymorphism on insulin resistance in healthy Iranian children and adolescentsTurkish journal of medical sciences · 2019Article
- Higher n-6:n-3 Fatty Acid Intake Is Associated with Decreased Cardiometabolic Risk Factors in a Racially Diverse Sample of Children.Current developments in nutrition · 2018Article
- Systemic FDiversity and equality in health and care · 2017Article
- The role of racial genetic admixture with endometrial cancer outcomes: An NRG Oncology/Gynecologic Oncology Group study.Gynecologic oncology · 2016Article
- Article
- Genetic admixture and obesity: recent perspectives and future applications.Human heredity · 2013Review
- Biogeographic ancestry, self-identified race, and admixture-phenotype associations in the Heart SCORE Study.American journal of epidemiology · 2012Article
- Beyond thriftiness: independent and interactive effects of genetic and dietary factors on variations in fat deposition and distribution across populations.American journal of physical anthropology · 2011Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate the contribution of European genetic admixture (EUADM) to insulin resistance syndrome (IRS) in a multiethnic sample of children age 7-12 years, and to explore whether body fat affects this relationship. STUDY
designAnthropometric measurements and blood pressure were assessed in 243 children. After an overnight fast, an intravenous glucose tolerance test was conducted, and measures of fasting insulin/glucose, lipids, insulin sensitivity (SI), and acute insulin response to glucose (AIRg) were obtained. The proportion of EUADM was determined by maximum likelihood estimation using 140 ancestry informative markers. Subjects were stratified into tertiles according to the proportion of EUADM for analyses. Subjects were categorized as lean or obese using body fat percentage cutpoints (25% in boys, 30% in girls).
resultsAmong lean subjects (72%), the tertile representing the greatest proportion of EUADM was associated with higher SI (P<.001) and serum glucose (P<.05) and lower insulin (P<.05), AIRg (P<.001), high-density lipoprotein cholesterol (P=.05), and blood pressure (P<.05). However, among obese subjects, EUADM was associated only with SI (P<.05).
conclusionsOur results suggest that population differences in IRS likely have a genetic component, but that the influence of genetic background may be masked by obesity.
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