ArticleActa biomaterialia2010
Biomimetic remineralization as a progressive dehydration mechanism of collagen matrices--implications in the aging of resin-dentin bonds.
Article in Acta biomaterialia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 93 citations in OpenAlex.
- The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for remineralization of artificial caries-like dentin.Dental materials : official publication of the Academy of Dental Materials · 2011Trial
- The critical barrier to progress in dentine bonding with the etch-and-rinse technique.Journal of dentistry · 2011Trial
- Biomimetic Enamel-like Crystals: A Versatile Platform for Unraveling the Basic Mechanisms of Demineralization and Remineralization.ACS applied materials & interfaces · 2025Article
- Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025Review
- The mechanism of biomineralization: Progress in mineralization from intracellular generation to extracellular deposition.The Japanese dental science review · 2023Review
- Polyphenols Can Improve Resin-Dentin Bond Durability by Promoting Amorphous Calcium Phosphate Nanoparticles to Backfill the Dentin Matrix.International journal of nanomedicine · 2023Article
- The Effect of Polyacrylic Acid and Sodium Trimetaphosphate on Dentin Hybrid Layer Remineralization: AnJournal of clinical and experimental dentistry · 2022Article
- Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review.Polymers · 2022Review
- Dentin remineralization in acidic solution without initial calcium phosphate ions via poly(amido amine) and calcium phosphate nanocomposites after fluid challenges.Clinical oral investigations · 2022Article
- Advances in biomineralization-inspired materials for hard tissue repair.International journal of oral science · 2021Review
- Traditional Microscopic Techniques Employed in Dental Adhesion Research-Applications and Protocols of Specimen Preparation.Biosensors · 2021Review
- A matched irrigation and obturation strategy for root canal therapy.Scientific reports · 2021Article
- Effect of Remineralized Collagen on Dentin Bond Strength through Calcium Phosphate Ion Clusters or Metastable Calcium Phosphate Solution.Nanomaterials (Basel, Switzerland) · 2020Article
- Effect of Chitosan as a Cross-Linker on Matrix Metalloproteinase Activity and Bond Stability with Different Adhesive Systems.Marine drugs · 2020Article
- Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles.International journal of oral science · 2019Review
- Contribution of biomimetic collagen-ligand interaction to intrafibrillar mineralization.Science advances · 2019Article
- Poly (amido amine) dendrimer and dental adhesive with calcium phosphate nanoparticles remineralized dentin in lactic acid.Journal of biomedical materials research. Part B, Applied biomaterials · 2018Article
- Nanomagnetic-mediated drug delivery for the treatment of dental disease.Nanomedicine : nanotechnology, biology, and medicine · 2018Article
- Improved secondary caries resistance via augmented pressure displacement of antibacterial adhesive.Scientific reports · 2016Article
- Synergistic intrafibrillar/extrafibrillar mineralization of collagen scaffolds based on a biomimetic strategy to promote the regeneration of bone defects.International journal of nanomedicine · 2016Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 6 countries.
Funding
Abstract
Biomineralization is a dehydration process in which water from the intrafibrillar compartments of collagen fibrils are progressively replaced by apatites. As water is an important element that induces a lack of durability of resin-dentin bonds, this study has examined the use of a biomimetic remineralization strategy as a progressive dehydration mechanism to preserve joint integrity and maintain adhesive strength after ageing. Human dentin surfaces were bonded with dentin adhesives, restored with resin composites and sectioned into sticks containing the adhesive joint. Experimental specimens were aged in a biomimetic analog-containing remineralizing medium and control specimens in simulated body fluid for up to 12 months. Specimens retrieved after the designated periods were examined by transmission electron microscopy for the presence of water-rich regions using a silver tracer and for collagen degradation within the adhesive joints. Tensile testing was performed to determine the potential loss of bond integrity after ageing. Control specimens exhibited severe collagen degradation within the adhesive joint after ageing. Remineralized specimens exhibited progressive dehydration, as manifested by silver tracer reduction and partial remineralization of water-filled microchannels within the adhesive joint, as well as intrafibrillar remineralization of collagen fibrils that were demineralized initially as part of the bonding procedure. Biomimetic remineralization as a progressive dehydration mechanism of water-rich, resin-sparse collagen matrices enables these adhesive joints to resist degradation over a 12-month ageing period, as verified by the conservation of their tensile bond strength. The ability of the proof of concept biomimetic remineralization strategy to prevent bond degradation warrants further development of clinically relevant delivery systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.