ReviewThe Journal of steroid biochemistry and molecular biology2010
Vitamin D and diabetes.
Review in The Journal of steroid biochemistry and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01141192 (The Effect of Vitamin D Supplementation on Glucose Metabolism in Non-Diabetic African American Adults), which is not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Vitamin D Supplementation on Glucose Metabolism in Non-Diabetic African American Adults
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Pooled it
- Vitamin D and Beta Cells in Type 1 Diabetes: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2015Trial
- Trial
- Effect of one time high dose "stoss therapy" of vitamin D on glucose homeostasis in high risk obese adolescents.Archives of endocrinology and metabolismTrial
- Vitamin D deficiency among Ethiopian adults: current evidence, determinants, and policy implications.Annals of medicine and surgery (2012) · 2026Review
- Association of serum 25-hydroxyvitamin D with urinary albumin-to-creatinine ratio and diabetic retinopathy in hospitalized patients with type 2 diabetes mellitus: a cross-sectional study.BMC endocrine disorders · 2026Article
- Exploring the Potential of Carotenoids in Obesity Management: A Comprehensive Overview.Recent advances in food, nutrition & agriculture · 2025Review
- Association between triglyceride-glucose index and vitamin D levels in Saudi postmenopausal women: a cross-sectional study.International journal of clinical and experimental pathology · 2025Article
- Effective counseling for children's bone health.Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- Vitamin D and Cardiovascular Diseases: An Update.Cureus · 2023Review
- The association of serum vitamin D with incident diabetes in an African American population.Nutrition & diabetes · 2022Article
- Review
- Vitamin D, parathyroid hormone, glucose metabolism and incident diabetes in the multiethnic study of atherosclerosis.BMJ open diabetes research & care · 2022Article
- Correlation between 25-hydroxy vitamin D levels in women and in vitro fertilization outcomes: A cross-sectional study.Annals of medicine and surgery (2012) · 2022Article
- Vitamin D, Vitamin D-Binding Proteins, and VDR Polymorphisms in Individuals with Hyperglycaemia.Nutrients · 2022Article
- Different Effects of Empagliflozin on Markers of Mineral-Bone Metabolism in Diabetic and Non-Diabetic Patients with Stage 3 Chronic Kidney Disease.Medicina (Kaunas, Lithuania) · 2021Article
- Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review.Nutrients · 2021Review
- Vitamin D and COVID-19: How Much Vitamin D Does a Man Need?Nutrients · 2021Article
- Shedding light on vitamin D: the shared mechanistic and pathophysiological role between hypovitaminosis D and COVID-19 risk factors and complications.Inflammopharmacology · 2021Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
On the basis of evidence from animal and human studies, vitamin D has emerged as a potential risk modifier for type 1 and type 2 diabetes (type 1 diabetes and type 2 diabetes). Vitamin D is thought to have both direct (through activation of the vitamin D receptor) and indirect (via regulation of calcium homeostasis) effects on various mechanisms related to the pathophysiology of both types of diabetes, including pancreatic beta-cell dysfunction, impaired insulin action and systemic inflammation. Observational case-control studies have shown that vitamin D supplementation in pregnancy or early childhood is associated with reduced risk of incident type 1 diabetes. There are no trials on the effect of vitamin D (ergocalciferol or cholecalciferol) on type 1 diabetes. An association between vitamin D insufficiency and incident type 2 diabetes has been reported in longitudinal observational studies, but the association is not consistent. Results from small underpowered trials and post-hoc analyses of data from larger trials designed for bone-specific outcomes show no effect of vitamin D supplementation on glycemia in healthy adults but vitamin D may retard the progression to diabetes in adults with glucose intolerance. Because vitamin D is an excellent marker of general health status, the positive results reported in some observational studies might reflect unmeasured and unaccounted confounding. Therefore, the hypothesis that vitamin D may modify diabetes risk needs to be confirmed in trials specifically designed for that purpose.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.