ArticleDevelopmental and comparative immunology2010
A novel functional rabbit IL-7 isoform.
Article in Developmental and comparative immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- What Are the Keys to the Adaptive Success of European Wild Rabbit (Animals : an open access journal from MDPI · 2021Review
- Bone marrow fat and the decline of B lymphopoiesis in rabbits.Developmental and comparative immunology · 2016Review
- An overview of the lagomorph immune system and its genetic diversity.Immunogenetics · 2016Review
- Molecular characterization and analysis of TLR-1 in rabbit tissues.Central-European journal of immunology · 2016Article
- Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.Innate immunity · 2015Article
- Diverse interleukin-7 mRNA transcripts in Chinese tree shrew (Tupaia belangeri chinensis).PloS one · 2014Article
- Somatically diversified and proliferating transitional B cells: implications for peripheral B cell homeostasis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
IL-7 is required for B cell development in mouse and is a key regulator of T cell development and peripheral T cell homeostasis in mouse and human. Recently, we found that IL-7 is expressed in rabbit bone marrow and in vitro, is required for differentiation of lymphoid progenitors to B and T lineage cells. Herein, we report the identification of a novel rabbit IL-7 isoform, IL-7II. Recombinant IL-7II (rIL-7II) binds lymphocytes via the IL-7R and induces phosphorylation of STAT5. Further, rIL-7II supports proliferation and differentiation of BM progenitor cells into B and T lineage cells. IL7-II is generated by alternative splicing, with an 11 amino acid insertion encoded by a separate exon, exon 2b. Exon 2b is conserved in other lagomorphs, in Perissodactyla, Artiodactyla, and Carnivora, but is absent in mouse and human.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.