ArticleBiophysical journal2010
Bipedal locomotion in crawling cells.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Nonlinear Stability in a Free Boundary Model of Active Locomotion.Archive for rational mechanics and analysis · 2026Article
- The Hungry Daemon: Does an Energy-Harvesting Active Particle Have to Obey the Second Law of Thermodynamics?Entropy (Basel, Switzerland) · 2025Article
- Active oscillations in microscale navigation.Animal cognition · 2023Review
- The Influence of Nucleus Mechanics in Modelling Adhesion-independent Cell Migration in Structured and Confined Environments.Bulletin of mathematical biology · 2023Article
- Optimal cell traction forces in a generalized motor-clutch model.Biophysical journal · 2023Article
- Polarity and mixed-mode oscillations may underlie different patterns of cellular migration.Scientific reports · 2023Article
- Hubbing the Cancer Cell.Cancers · 2022Review
- Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration.Current biology : CB · 2021Article
- Stick-slip model for actin-driven cell protrusions, cell polarization, and crawling.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Nonlinear Elastic and Inelastic Properties of Cells.Journal of biomechanical engineering · 2020Review
- CompuCell3D Simulations Reproduce Mesenchymal Cell Migration on Flat Substrates.Biophysical journal · 2020Article
- A minimal mechanosensing model predicts keratocyte evolution on flexible substrates.Journal of the Royal Society, Interface · 2020Article
- Excitable networks controlling cell migration during development and disease.Seminars in cell & developmental biology · 2020Review
- Mechanochemical Coupling and Junctional Forces during Collective Cell Migration.Biophysical journal · 2019Article
- The excitable signal transduction networks: movers and shapers of eukaryotic cell migration.The International journal of developmental biology · 2019Review
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- Spontaneous migration of cellular aggregates from giant keratocytes to running spheroids.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Keratocytes Generate High Integrin Tension at the Trailing Edge to Mediate Rear De-adhesion during Rapid Cell Migration.iScience · 2018Article
- Excitable Signal Transduction Networks in Directed Cell Migration.Annual review of cell and developmental biology · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Many complex cellular processes from mitosis to cell motility depend on the ability of the cytoskeleton to generate force. Force-generating systems that act on elastic cytoskeletal elements are prone to oscillating instabilities. In this work, we have measured spontaneous shape and movement oscillations in motile fish epithelial keratocytes. In persistently polarized, fan-shaped cells, retraction of the trailing edge on one side of the cell body is out of phase with retraction on the other side, resulting in periodic lateral oscillation of the cell body. We present a physical description of keratocyte oscillation in which periodic retraction of the trailing edge is the result of elastic coupling with the leading edge. Consistent with the predictions of this model, the observed frequency of oscillation correlates with cell speed. In addition, decreasing the strength of adhesion to the substrate reduces the elastic force required for retraction, causing cells to oscillate with higher frequency at relatively lower speeds. These results demonstrate that simple elastic coupling between movement at the front of the cell and movement at the rear can generate large-scale mechanical integration of cell behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.