Trial reportJournal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation2010
Folic acid supplementation and cardiac and stroke mortality among hemodialysis patients.
Trial report in Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antidepressants for treating depression in adults with end-stage kidney disease treated with dialysis.The Cochrane database of systematic reviews · 2016Pooled it
- Associations between homocysteine, vitamin B12, and folate and the risk of all-cause mortality in American adults with stroke.Frontiers in nutrition · 2023Article
- Associations of fish oil and vitamin B and E supplementation with cardiovascular outcomes and mortality in people receiving haemodialysis: a review.BMC nephrology · 2015Review
- Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress.BMC complementary and alternative medicine · 2011Article
- Association between adherence to folic acid supplements and serum folate, and plasma homocysteine among hemodialysis patients.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveWe sought to assess whether the use of folic acid vitamin supplements reduced cardiac and stroke mortality in hemodialysis patients. Further, we examined whether the consumption of folic acid from vitamin supplements >1000 microg compared with the standard 1000 microg, and 1000 microg compared with either a lower dose or no consumption, were associated with reduced cardiac and stroke mortality risk.
designWe performed a secondary analysis of data from the Hemodialysis Study, a randomized clinical trial examining dialysis treatment regimens over a 3-year follow-up.
participantsParticipants included 1846 hemodialysis patients previously participating in the Hemodialysis Study.
interventionsThere were no interventions.
main outcome measureCardiac and stroke mortality were our main outcome measures.
resultsBased on time-dependent Cox proportional hazard regression models, folic acid consumption from vitamin supplements, above or below the standard 1000-microg dose, was not associated with a decrease or increase in cardiac mortality (P = .53, above vs. standard dose; P = .46, below vs. standard dose). There was also no association between folic acid consumption and mortality from stroke (P = .27, above vs. standard dose; P = .64, below vs. standard dose).
conclusionThe consumption of higher than the standard 1000-microg prescribed dose of folic acid was not beneficial in reducing cardiac or stroke mortality in hemodialysis patients. Similarly, the consumption of less than the standard dose was not associated with an increase in either cardiac or stroke mortality.
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Registered trials
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