ArticleInternational journal of cardiology2011
Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic women.
Article in International journal of cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- The effects of resistance training on ApoB/ApoA-I ratio, Lp(a) and inflammatory markers in patients with type 2 diabetes.Endocrine · 2012Trial
- Lipoprotein(a) as a Risk Factor for Myocardial Infarction, Cardiovascular, and All-Cause Mortality in Patients with Type 2 Diabetes Mellitus.Diagnostics (Basel, Switzerland) · 2026Article
- Enhanced independent discriminative performance of elevated lipoprotein(a) for cardiovascular outcomes in patients with diabetes: a comparative analysis of optimal cutoff values.Frontiers in endocrinology · 2026Article
- The Association of Lipoprotein(A) and Coronary Artery Calcium in Primary Prevention Patients-Data from the STAR-Lp(A) Study.Journal of clinical medicine · 2025Article
- Association between lipoprotein(a) and atherosclerosis with different diabetic status: a cross-sectional study in a Chinese population.Cardiovascular diagnosis and therapy · 2025Article
- Lipoprotein(a) is associated with a larger systemic burden of arterial calcification.European heart journal. Cardiovascular Imaging · 2023Article
- Association between lipoprotein(a) and peripheral arterial disease in coronary artery bypass grafting patients.Clinical cardiology · 2023Article
- Lipoprotein(a), Cardiovascular Events and Sex Differences: A Single Cardiological Unit Experience.Journal of clinical medicine · 2023Article
- Lipoprotein(a) and Subclinical Vascular and Valvular Calcification on Cardiac Computed Tomography: The Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2022Article
- Coronary artery calcium scoring as a tool for risk stratification in patients with an elevated lipoprotein(a) level.Frontiers in cardiovascular medicine · 2022Article
- Correlations Between Coronary Artery Disease, Coronary Artery Calcium Score, and Lipoprotein(a) Level in Korea.Therapeutics and clinical risk management · 2022Article
- Metabolic syndrome, lipoprotein(a) and subclinical atherosclerosis in Mexican populationArchivos de cardiologia de Mexico · 2021Article
- Sex-Specific Association between Serum 25-Hydroxyvitamin D and Metabolic Risk Factors in T2DM Patients.International journal of endocrinology · 2020Article
- Evaluating the Potential Association Between Lipoprotein(a) and Atherosclerosis (from the Mediators of Atherosclerosis Among South Asians Living in America Cohort).The American journal of cardiology · 2019Article
- Race-Based Differences in Lipoprotein(a)-Associated Risk of Carotid Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology.Journal of community health · 2018Review
- Immunomodulatory effects of adipose tissue-derived stem cells on elastin scaffold remodeling in diabetes.Tissue engineering and regenerative medicine · 2016Article
- Function, Role, and Clinical Application of MicroRNAs in Vascular Aging.BioMed research international · 2016Review
- Apolipoprotein(a) Kringle-IV Type 2 Copy Number Variation Is Associated with Venous Thromboembolism.PloS one · 2016Article
- The Role of Epigenetics in Arterial Calcification.BioMed research international · 2015Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLp(a), implicated in both atherogenesis and thrombosis pathways, varies significantly by demographic and metabolic factors, providing challenges for its use in Coronary Heart Disease (CHD) risk. The purpose of this study was to investigate whether type-2 diabetic subjects, relative to non-diabetics, might benefit more from Lp(a) measurement in the prediction of CHD risk, as measured by coronary artery calcium (CAC).
methodsWe performed cross sectional analyses in two community-based studies: the Penn Diabetes Heart Study [N = 1299 with type-2 diabetes] and the Study of Inherited Risk of Coronary Atherosclerosis [N = 860 without diabetes].
resultsBlacks had 2-3 fold higher Lp(a) levels than whites in diabetic and non-diabetic samples. There was significant difference by gender (interaction p<0.001), but not race, in the association of Lp(a) with CAC in type-2 diabetic subjects. In age and race adjusted analysis of diabetic women, Lp(a) was associated with CAC [Tobit regression ratio 2.76 (95% CI 1.73-4.40), p<0.001]. Adjustment for exercise, medications, Framingham risk score, metabolic syndrome, BMI, CRP and hemoglobin A1c attenuated this effect, but the association of Lp(a) with CAC remained significant [2.25, (1.34-3.79), p = 0.002]. This relationship was further maintained in women stratified by race, or by the use of HRT or lipid lowering drugs. In contrast, Lp(a) was not associated with CAC in diabetic men, nor in non-diabetic men and women.
conclusionsLp(a) is a strong independent predictor of CAC in type-2 diabetic women, regardless of race, but not in men. Lp(a) does not relate to CAC in men or women without type-2 diabetes.
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Registered trials
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