Evidence map›Paper›PMID 20303034›Full record

ReviewTransfusion medicine reviews2010

Blood still kills: six strategies to further reduce allogeneic blood transfusion-related mortality.

Eleftherios C Vamvakas, Morris A Blajchman

Erratum issued Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Transfusion medicine reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06753188 (Clinical Pattern of Glanzemnn Thrombathenia in Children Attending Assiut University Children Hospital), which is not on this map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06753188 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical Pattern of Glanzemnn Thrombathenia in Children Attending Assiut University Children Hospital

TypeobservationalSponsorAssiut UniversityRan2025 to 2026Enrolled50ConditionsGlanzemnn Thrombathenia
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 191 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Commentary: Culture trumps (transfusion) guidelines.The Journal of thoracic and cardiovascular surgery · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Utilisation of emergency blood in a cohort of South African emergency centres with no direct access to a blood bank.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2019
    Article
  17. Article
  18. Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019
    Review
  19. Role of Thromboelastography and Rotational Thromboelastometry in the Management of Cardiovascular Diseases.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018
    Review
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Eleftherios C VamvakasDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Vamvakase@cshs.org
Morris A Blajchman
Canadian Blood Services · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After reviewing the relative frequency of the causes of allogeneic blood transfusion-related mortality in the United States today, we present 6 possible strategies for further reducing such transfusion-related mortality. These are (1) avoidance of unnecessary transfusions through the use of evidence-based transfusion guidelines, to reduce potentially fatal (infectious as well as noninfectious) transfusion complications; (2) reduction in the risk of transfusion-related acute lung injury in recipients of platelet transfusions through the use of single-donor platelets collected from male donors, or female donors without a history of pregnancy or who have been shown not to have white blood cell (WBC) antibodies; (3) prevention of hemolytic transfusion reactions through the augmentation of patient identification procedures by the addition of information technologies, as well as through the prevention of additional red blood cell alloantibody formation in patients who are likely to need multiple transfusions in the future; (4) avoidance of pooled blood products (such as pooled whole blood-derived platelets) to reduce the risk of transmission of emerging transfusion-transmitted infections (TTIs) and the residual risk from known TTIs (especially transfusion-associated sepsis [TAS]); (5) WBC reduction of cellular blood components administered in cardiac surgery to prevent the poorly understood increased mortality seen in cardiac surgery patients in association with the receipt of non-WBC-reduced (compared with WBC-reduced) transfusion; and (6) pathogen reduction of platelet and plasma components to prevent the transfusion transmission of most emerging, potentially fatal TTIs and the residual risk of known TTIs (especially TAS).

Indexed as

Acute Lung InjuryBlood-Borne PathogensBlood TransfusionDisease Transmission, InfectiousDonor SelectionEvidence-Based MedicineFemaleGuideline AdherenceHemolysisHumansMalePregnancySafety ManagementTransfusion ReactionTransplantation, Homologous

Identifiers

PMID20303034
PMCPMC7126657
OpenAlexW2140813614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.