ArticleNeuropharmacology2010
Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine.
Article in Neuropharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Discriminative stimulus and locomotor activity profiles of nicotine and varenicline.Pharmacology, biochemistry, and behavior · 2026Article
- The inside story: Interoceptive Pavlovian conditioning with the nicotine stimulus.Journal of experimental psychology. Animal learning and cognition · 2025Review
- Understanding the stimulus effects of nicotine and bupropion in a drug-drug discriminated goal-tracking task.Psychopharmacology · 2022Article
- The importance of acquisition learning on nicotine and varenicline drug substitution in a drug-discriminated goal-tracking task.Pharmacology, biochemistry, and behavior · 2020Article
- Exploring the interoceptive stimulus effects of nicotine and varenicline.Pharmacology, biochemistry, and behavior · 2019Article
- Cocaine preexposure enhances sexual conditioning and increases resistance to extinction in male Japanese quail.Learning & behavior · 2017Article
- The effect of sazetidine-A and other nicotinic ligands on nicotine controlled goal-tracking in female and male rats.Neuropharmacology · 2017Article
- The nicotine + alcohol interoceptive drug state: contribution of the components and effects of varenicline in rats.Psychopharmacology · 2016Article
- The effect of switching pharmacological intervention during extinction on nicotine-evoked conditioned responding in rats.Psychopharmacology · 2015Article
- Interoceptive conditioning with nicotine using extinction and re-extinction to assess stimulus similarity with bupropion.Neuropharmacology · 2014Article
- Interoception and learning: import to understanding and treating diseases and psychopathologies.ACS chemical neuroscience · 2014Review
- Effects of chronic varenicline treatment on nicotine, cocaine, and concurrent nicotine+cocaine self-administration.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Interoceptive conditioning in rats: effects of using a single training dose or a set of 5 different doses of nicotine.Pharmacology, biochemistry, and behavior · 2013Article
- Iptakalim attenuates self-administration and acquired goal-tracking behavior controlled by nicotine.Neuropharmacology · 2013Article
- Interoceptive conditioning with a nicotine stimulus is susceptible to reinforcer devaluation.Behavioral neuroscience · 2013Article
- Disentangling the nature of the nicotine stimulus.Behavioural processes · 2012Review
- Nicotine modulates alcohol-seeking and relapse by alcohol-preferring (P) rats in a time-dependent manner.Alcoholism, clinical and experimental research · 2012Article
- Diminished conditioned responding to the nicotine stimulus by antidepressant drugs with differing specificity for the serotonin and norepinephrine transporter.Pharmacology, biochemistry, and behavior · 2012Article
- Nicotine trained as a negative feature passes the retardation-of-acquisition and summation tests of a conditioned inhibitor.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The interoceptive stimulus effects of nicotine acquire control over behavior. This observation, among others, suggests that the stimulus effects of nicotine are important in the development and tenacity of tobacco dependence. Despite this importance, there has been little research examining whether non-reinforced presentations (extinction) of a ligand that share stimulus effects of nicotine will weaken responding controlled by nicotine. Rats were trained to discriminate nicotine (0.4 mg/kg) from saline using a discriminated goal-tracking task in which nicotine signaled intermittent access to sucrose; sucrose was withheld on saline sessions. Experiment 1 examined substitution for nicotine by ABT-418, nornicotine, epibatidine, varenicline, or cytisine in 4-min extinction tests. Experiments 2-5 [low-dose nicotine (0.05 mg/kg), ABT-418, nornicotine, or varenicline, respectively] examined whether substitution for nicotine would persist if extinction tests were increased to 20 min and repeated daily for 6 days. Finally, generalization of this extinction back to the nicotine training stimulus was assessed. Full substitution in brief 4-min extinction tests was seen for ABT-418, nornicotine, epibatidine, varenicline, and cytisine. Low-dose nicotine, ABT-418, nornicotine, and varenicline, evoked only a partial 'nicotine-like' response in the first 20-min extinction test. With repeated extinction, only low-dose nicotine, nornicotine, and varenicline continued to substitute. Extinction with nornicotine and varenicline transferred back to nicotine as indicated by a partial conditioned response to the training stimulus. Interpretations regarding 'nicotine-like' effects of a ligand depend on the nature of the test. Understanding the processes mediating transfer of extinction learning with potential pharmacotherapies may reveal new treatment targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.