ArticleBMC genomics2010
Antimicrobial peptide-like genes in Nasonia vitripennis: a genomic perspective.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- Synergistic host-parasitoid antimicrobial peptide interactions ensure the survival of parasitized hosts.Virulence · 2025Article
- Evolution of five environmentally responsive gene families in a pine-feeding sawfly,Ecology and evolution · 2023Article
- Toll and IMD Immune Pathways Are Important Antifungal Defense Components in a Pupal Parasitoid,International journal of molecular sciences · 2023Article
- Effects of Local and Systemic Immune Challenges on the Expression of Selected Salivary Genes in the Malaria MosquitoPathogens (Basel, Switzerland) · 2021Article
- Parallel identification of novel antimicrobial peptide sequences from multiple anuran species by targeted DNA sequencing.BMC genomics · 2018Article
- Antimicrobial peptide gene BdPho responds to peptidoglycan infection and mating stimulation in oriental fruit fly, Bactrocera dorsalis (Hendel).AMB Express · 2018Article
- Convergent evolution of defensin sequence, structure and function.Cellular and molecular life sciences : CMLS · 2017Review
- Diversity, evolution and medical applications of insect antimicrobial peptides.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Disentangling a Holobiont - Recent Advances and Perspectives inFrontiers in microbiology · 2016Review
- Article
- Evolutionary genetics of insect innate immunity.Briefings in functional genomics · 2015Review
- EST-based in silico identification and in vitro test of antimicrobial peptides in Brassica napus.BMC genomics · 2015Article
- Scrutinizing the immune defence inventory of Camponotus floridanus applying total transcriptome sequencing.BMC genomics · 2015Article
- Genetic and epigenetic architecture of sex-biased expression in the jewel wasps Nasonia vitripennis and giraulti.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Biologically active and antimicrobial peptides from plants.BioMed research international · 2015Review
- The fungal defensin family enlarged.Pharmaceuticals (Basel, Switzerland) · 2014Review
- Production of homozygous transgenic rainbow trout with enhanced disease resistance.Marine biotechnology (New York, N.Y.) · 2014Article
- A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster.BMC genetics · 2014Article
- Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment.Genome biology · 2014Article
- Obligate mutualism within a host drives the extreme specialization of a fig wasp genome.Genome biology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntimicrobial peptides (AMPs) are an essential component of innate immunity which can rapidly respond to diverse microbial pathogens. Insects, as a rich source of AMPs, attract great attention of scientists in both understanding of the basic biology of the immune system and searching molecular templates for anti-infective drug design. Despite a large number of AMPs have been identified from different insect species, little information in terms of these peptides is available from parasitic insects.
resultsBy using integrated computational approaches to systemically mining the Hymenopteran parasitic wasp Nasonia vitripennis genome, we establish the first AMP repertoire whose members exhibit extensive sequence and structural diversity and can be distinguished into multiple molecular types, including insect and fungal defensin-like peptides (DLPs) with the cysteine-stabilized alpha-helical and beta-sheet (CSalphabeta) fold; Pro- or Gly-rich abaecins and hymenoptaecins; horseshoe crab tachystatin-type AMPs with the inhibitor cystine knot (ICK) fold; and a linear alpha-helical peptide. Inducible expression pattern of seven N. vitripennis AMP genes were verified, and two representative peptides were synthesized and functionally identified to be antibacterial. In comparison with Apis mellifera (Hymenoptera) and several non-Hymenopteran model insects, N. vitripennis has evolved a complex antimicrobial immune system with more genes and larger protein precursors. Three classical strategies that are likely responsible for the complexity increase have been recognized: 1) Gene duplication; 2) Exon duplication; and 3) Exon-shuffling.
conclusionThe present study established the N. vitripennis peptidome associated with antimicrobial immunity by using a combined computational and experimental strategy. As the first AMP repertoire of a parasitic wasp, our results offer a basic platform for further studying the immunological and evolutionary significances of these newly discovered AMP-like genes in this class of insects.
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