ArticleLangmuir : the ACS journal of surfaces and colloids2010
Investigating lyophilization of lipid nanocapsules with fluorescence correlation spectroscopy.
Article in Langmuir : the ACS journal of surfaces and colloids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Nanocapsules: the weapons for novel drug delivery systems.BioImpacts : BI · 2012Article
- Article
- Optical Trapping Enabled Parallel Delivery of Biological Stimuli with High Spatial and Temporal Resolution.Proceedings of SPIE--the International Society for Optical Engineering · 2010Article
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Authors and funding
3 authors.
Funding
Abstract
This paper describes characterization of lyophilized lipid nanocapsules loaded with Alexa 488 by fluorescence correlation spectroscopy (FCS). Fluorimetry analysis of nanocapsules containing self-quenching concentrations of 5- and 6-carboxyfluorescein was performed to establish a point of reference for FCS. FCS results complemented the results obtained by fluorimetry for a bulk nanocapsule solution and provided additional information about the size and dye retention by individual nanocapsules. Using this method, we determined that nanocapsules composed of the thiol-functionalized lipids showed the best dye retention and the most consistent results. Dye retention, size, and photolysis efficiency of these thiol-functionalized nanocapsules doped with a far-red photosensitizer did not change substantially upon lyophilization and storage at -20 degrees C for up to 2 months, making lyophilization a suitable method for the long-term storage of nanocapsules with the appropriate lipid composition.
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Registered trials
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