ArticleJournal of clinical pathology1991
Influenza A and the virus associated haemophagocytic syndrome: cluster of three cases in children with acute leukaemia.
Article in Journal of clinical pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Influenza vaccination in children being treated with chemotherapy for cancer.The Cochrane database of systematic reviews · 2013Pooled it
- Safety of high dose trivalent inactivated influenza vaccine in pediatric patients with acute lymphoblastic leukemia.Pediatric blood & cancer · 2014Trial
- Cytokine Storm Syndrome Associated with Hemorrhagic Fever and Other Viruses.Advances in experimental medicine and biology · 2024Review
- A prospective study of chemotherapy immunologic effects and predictors of humoral influenza vaccine responses in a pediatric oncology cohort.Influenza and other respiratory viruses · 2013Article
- Debate around infection-dependent hemophagocytic syndrome in paediatrics.BMC infectious diseases · 2013Review
- Protecting pediatric oncology patients from influenza.The oncologist · 2013Review
- A case of novel swine influenza A (H1N1) pneumonia complicated with virus-associated hemophagocytic syndrome.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2012Article
- Is Swine-origin Influenza a Predisposing Factor for Deep Vein Thrombosis?Turkish journal of haematology : official journal of Turkish Society of Haematology · 2012Article
- Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection.Critical care (London, England) · 2011Article
- Viral infections associated with haemophagocytic syndrome.Reviews in medical virology · 2010Review
- Infections associated with haemophagocytic syndrome.The Lancet. Infectious diseases · 2007Review
- Infection-associated haemophagocytic syndrome associated with recurrent acute myeloid leukaemia/myelodysplastic syndrome: an autopsy case.Journal of clinical pathology · 2007Article
- Influenza A virus-associated encephalopathy with haemophagocytic syndrome.European journal of pediatrics · 2003Article
- Response to influenza immunisation during treatment for cancer.Archives of disease in childhood · 2001Article
- Potential specific therapies in COVID-19.Therapeutic advances in respiratory diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At the height of the United Kingdom influenza A epidemic in December 1989, three children receiving treatment for non-T cell acute leukaemia developed pancytopenia with concomitant influenza A infection. Bone marrow histology showed prominent marrow erythrophagocytosis by morphologically mature histiocytes, consistent with the picture of virus associated haemophagocytic syndrome (VAHS). In two cases there was an initial spontaneous recovery, though recurrence of VAHS developed in one case in association with a different viral infection (cytomegalovirus) following autologous bone marrow transplantation. The third child died from cardiorespiratory failure secondary to infection with influenza A and Klebsiella pneumoniae sepsis. It is suggested that influenza A should be added to the list of infective causative agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.