ArticleAdvanced materials (Deerfield Beach, Fla.)2010
Glyconanomaterials: synthesis, characterization, and ligand presentation.
Article in Advanced materials (Deerfield Beach, Fla.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 111 citations in OpenAlex.
- Mannan oligosaccharide-S. typhimurium interaction mediated fluorescent-recovery of carbon dots/molybdenum disulfide probe for rapid detection.Mikrochimica acta · 2026Article
- Synthesis, Antimicrobial Activity, DFT, Molecular Docking, and Dynamic Simulations of Trityl Mannopyranoside Derivatives for Potential Antibacterial Agents.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025Article
- Polymers in Physics, Chemistry and Biology: Behavior of Linear Polymers in Fractal Structures.Polymers · 2024Review
- Turning on the Antimicrobial Activity of Gold Nanoclusters Against Multidrug-Resistant Bacteria.Angewandte Chemie (International ed. in English) · 2023Article
- A universal strategy of glyconanoparticle preparation using a bifunctional linker for lectin sensing and cell imaging.Mikrochimica acta · 2022Article
- Glycopolymer-Wrapped Carbon Nanotubes Show Distinct Interaction of Carbohydrates With Lectins.Frontiers in chemistry · 2022Article
- Exploring Carbohydrates for Therapeutics: A Review on Future Directions.Frontiers in pharmacology · 2021Review
- Quantification of binding affinity of glyconanomaterials with lectins.Chemical communications (Cambridge, England) · 2020Review
- Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor.International journal of molecular sciences · 2019Article
- Immobilization of glycans on solid surfaces for application in glycomics.Journal of carbohydrate chemistry · 2018Article
- Review
- Presenting Precision Glycomacromolecules on Gold Nanoparticles for Increased Lectin Binding.Polymers · 2017Article
- Glyconanomaterials for biosensing applications.Biosensors & bioelectronics · 2016Review
- Glyconanomaterials for Combating Bacterial Infections.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles.Chemical communications (Cambridge, England) · 2015Article
- Synthesis of multifunctional cellulose nanocrystals for lectin recognition and bacterial imaging.Biomacromolecules · 2015Article
- Polysaccharide-based nanocomposites and their applications.Carbohydrate research · 2015Review
- Probing multivalency in ligand-receptor-mediated adhesion of soft, biomimetic interfaces.Beilstein journal of organic chemistry · 2015Article
- Targeting breast cancer with sugar-coated carbon nanotubes.Nanomedicine (London, England) · 2015Article
- Glyconanomaterials: Emerging applications in biomedical research.Nano research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Glyconanomaterials, nanomaterials carrying surface-tethered carbohydrate ligands, have emerged and demonstrated increasing potential in biomedical imaging, therapeutics, and diagnostics. These materials combine the unique properties of nanometer-scale objects with the ability to present multiple copies of carbohydrate ligands, greatly enhancing the weak affinity of individual ligands to their binding partners. Critical to the performance of glyconanomaterials is the proper display of carbohydrate ligands, taking into consideration of the coupling chemistry, the type and length of the spacer linkage, and the ligand density. This article provides an overview of the coupling chemistry for attaching carbohydrate ligands to nanomaterials, and discusses the need for thorough characterization of glyconanomaterials, especially quantitative analyses of the ligand density and binding affinities. Using glyconanoparticles synthesized by a versatile photocoupling chemistry, methods for determining the ligand density by colorimetry and the binding affinity with lectins by a fluorescence competition assay are determined. The results show that the multivalent presentation of carbohydrate ligands significantly enhances the binding affinity by several orders of magnitude in comparison to the free ligands in solution. The effect is sizeable even at low surface ligand density. The type and length of the spacer linkage also affect the binding affinity, with the longer linkage promoting the association of bound ligands with the corresponding lectins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.