ArticleMedical oncology (Northwood, London, England)2011
Growth inhibitory effects of DJ-1-small interfering RNA on laryngeal carcinoma Hep-2 cells.
Article in Medical oncology (Northwood, London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression.Journal of clinical medicine · 2020Review
- Differentially expressed proteins in positive versus negative HNSCC lymph nodes.BMC medical genomics · 2018Article
- [Effect of DJ-1 silencing by RNA interference on growth of xenografted human laryngeal squamous cell carcinoma Hep-2 cells in nude mice].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Article
- Blocking eIF5A modification in cervical cancer cells alters the expression of cancer-related genes and suppresses cell proliferation.Cancer research · 2014Article
- Long non-coding RNA profiling in laryngeal squamous cell carcinoma and its clinical significance: potential biomarkers for LSCC.PloS one · 2014Article
- Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma.Journal of experimental & clinical cancer research : CR · 2012Article
- The role of cysteine oxidation in DJ-1 function and dysfunction.Antioxidants & redox signaling · 2011Review
- Significance and relationship between DJ-1 gene and surviving gene expression in laryngeal carcinoma.European journal of histochemistry : EJH · 2011Article
- The role of DJ-1 in the pathogenesis of endometriosis.PloS one · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer of the larynx is the commonest head and neck squamous cell carcinoma. The DJ-1 gene is a novel mitogen-dependent oncogene. Survivin is a structurally unique member of the inhibitors of apoptosis proteins. DJ-1 and survivin play important roles in carcinogenesis. The function of DJ-1, and the relationship between DJ-1 and survivin in laryngeal carcinoma, has never been explored. Small interfering RNAs (siRNAs) directed against the DJ-1 gene were initially transfected into laryngeal carcinoma Hep-2 cells with liposome. The viability of Hep-2 cells was then detected by the MTT assay. The changes in cell-cycle distribution were monitored by flow cytometry. Finally, changes in DJ-1 and survivin genes mRNA and protein levels were evaluated by semi-quantitative RT-PCR and Western blotting, respectively. Blocking expression of the DJ-1 gene with DJ-1-siRNA significantly suppressed the viability of Hep-2 cells. Treatment with DJ-1-siRNA resulted in a G2/M accumulation. Expressions of DJ-1 and survivin gene mRNA and protein levels were suppressed by DJ-1-siRNA in a dose-dependent manner. These data indicate, for the first time, that the DJ-1 gene may have an important role in the carcinogenesis of laryngeal carcinoma.
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