ArticleEuropean journal of applied physiology2010
Exercise training-induced enhancement in myocardial mechanics is lost after 2 weeks of detraining in rats.
Article in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prior exercise training and experimental myocardial infarction: A systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2020Pooled it
- The effects of detraining on blood adipokines and antioxidant enzyme in Korean overweight children.European journal of pediatrics · 2012Trial
- Strength training improves heart function, collagen and strength in rats with heart failure.The journal of physiological sciences : JPS · 2024Article
- Effects of physical training on the metabolic profile of rats exposed to chronic restraint stress.Clinics (Sao Paulo, Brazil) · 2024Article
- Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/Nrf2 pathway.Biogerontology · 2023Article
- Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin.American journal of physiology. Heart and circulatory physiology · 2021Article
- Short-Term Cigarette Smoking in Rats Impairs Physical Capacity and Induces Cardiac Remodeling.BioMed research international · 2020Article
- Delayed Reperfusion-Coronary Artery Reperfusion Close to Complete Myocardial Necrosis Benefits Remote Myocardium and Is Enhanced by Exercise.Frontiers in physiology · 2019Article
- Moderate Physical Training Ameliorates Cardiovascular Dysfunction Induced by High Fat Diet After Cessation of Training in Adult Rats.Frontiers in physiology · 2019Article
- Contribution of Heme Oxygenase 2 to Blood Pressure Regulation in Response to Swimming Exercise and Detraining in Spontaneously Hypertensive Rats.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Sustained cardiac programming by short-term juvenile exercise training in male rats.The Journal of physiology · 2018Article
- The effects of detraining and training on adipose tissue lipid droplet in obese mice after chronic high-fat diet.Lipids in health and disease · 2017Article
- Detraining in pregnancy and/or lactation modulates neuropeptidergic hypothalamic systems in offspring mice.Endocrine · 2015Article
- Cardiac adaptations from 4 weeks of intensity-controlled vigorous exercise are lost after a similar period of detraining.Physiological reports · 2015Article
- Treadmill exercise training prevents myocardial mechanical dysfunction induced by androgenic-anabolic steroid treatment in rats.PloS one · 2014Article
- Physiological adaptations during endurance training below anaerobic threshold in rats.European journal of applied physiology · 2013Article
- Ventricular and autonomic benefits of exercise training persist after detraining in infarcted rats.European journal of applied physiology · 2013Article
- Exercise attenuates renal dysfunction with preservation of myocardial function in chronic kidney disease.PloS one · 2013Article
- Physical activity, adiponectin, and cardiovascular structure and function.Heart and vessels · 2013Article
- Akt and MAPK signaling mediate pregnancy-induced cardiac adaptation.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise training is assumed to improve myocardial function; however, the role of detraining and its effect on myocardial parameters are still unclear. The aim of the present study was to evaluate the effect of detraining on ventricular remodeling and myocardial mechanical parameters after an 8 week (5 days/week, 60 min/day) swimming training period. Forty-three female Wistar rats were distributed into six groups: trained (T, n = 9), detrained 2 weeks (D2, n = 8), detrained 4 weeks (D4, n = 8) and their respective controls: untrained (U, n = 5), untrained 2 weeks (U2, n = 5) and untrained 4 weeks (U4, n = 5). Detrained rats underwent training and then remained sedentary (i.e., "detraining") for 2 or 4 weeks. After training, the T group demonstrated increased physical capacity, left ventricular (LV) posterior wall thickness, and LV end-diastolic diameter, along with decreased heart rate, as evaluated by echocardiogram. In addition, the inotropism and lusitropism parameters studied on papillary muscles showed improvement in the T group (P < 0.05). However, after just 2 weeks of detraining, all parameters regressed back to values which were similar to those of the untrained groups. In conclusion, our results confirmed that exercise training is capable of inducing myocardial remodeling and improving contractile performance; however, these changes are completely lost after a short period of detraining.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.