Trial reportEuropean journal of clinical pharmacology2010
Paracetamol for intravenous use in medium--and intensive care patients: pharmacokinetics and tolerance.
Trial report in European journal of clinical pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: a Randomized Controlled Trial
Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].Schmerz (Berlin, Germany) · 2014Guideline
- The hemodynamic effects of intravenous paracetamol (acetaminophen) in patients with chronic liver disease undergoing liver transplantation: a pilot study.BMC research notes · 2021Trial
- Trial
- The haemodynamic effects of intravenous paracetamol (acetaminophen) in healthy volunteers: a double-blind, randomized, triple crossover trial.British journal of clinical pharmacology · 2016Trial
- Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults.European journal of drug metabolism and pharmacokinetics · 2023Article
- The Effects of Pain and Analgesic Medications on Blood Pressure.Current hypertension reports · 2022Review
- Risk Factors for Intravenous Propacetamol-Induced Blood Pressure Drop in the Neurointensive Care Unit: A Retrospective Observational Study.Neurocritical care · 2022Observational
- Review
- Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Hemodynamic effects of intravenous paracetamol in critically ill children with septic shock on inotropic support.Journal of intensive care · 2020Article
- The Hemodynamic Effect of Intravenous Paracetamol in Children: A Retrospective Chart Review.Paediatric drugs · 2019Review
- Paracetamol clinical dosing routine leads to paracetamol underexposure in an adult severely ill sub-Saharan African hospital population: a drug concentration measurement study.BMC research notes · 2017Article
- Clinically significant hemodynamic alterations after propacetamol injection in the emergency department: prevalence and risk factors.Internal and emergency medicine · 2017Article
- [Analgesia in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2016Review
- Clinical pharmacology of paracetamol in neonates: a review.Current therapeutic research, clinical and experimental · 2015Review
- Paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration.Heart, lung and vessels · 2015Review
- Covariates of intravenous paracetamol pharmacokinetics in adults.BMC anesthesiology · 2014Article
- The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings.Inflammopharmacology · 2013Review
- [Paracetamol for perioperative analgesia. Old substance - new insights].Der Anaesthesist · 2010Article
- Haemodynamics of intravenous paracetamol in neonates.European journal of clinical pharmacology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe studied the pharmacokinetics of paracetamol and determine the incidence of hypotension after intravenous administration in medium- (MCU) and intensive care (ICU) patients.
methodsAll patients on the ICU/MCU starting with paracetamol i.v. were included, yielding 38 patients. Blood samples were collected at predetermined time points to determine paracetamol serum concentration. The number of patients with a clinically relevant reduction in systolic blood pressure (SBP) and the number of patients that needed intervention to regain an acceptable blood pressure level were assessed.
resultsOverall, pharmacokinetic data were roughly comparable with earlier publications, but differences were noted in the subgroup ICU patients. Also, there was a trend to a larger peak serum concentration (p = 0.052) and a significantly smaller volume of distribution (p = 0.033) in MCU patients compared with ICU patients. Twenty-two percent (22%) and 33% of patients had a clinically relevant reduction in systolic blood pressure (SBP) 15 and 30 min after start of paracetamol infusion, respectively. In six patients (16%), an intervention was needed to correct blood pressure. Overall, SBP was significantly reduced at T = 15 min and 30 min postinfusion (p < 0.003 at both time points) when compared with SBP at the start of paracetamol infusion.
conclusionsFurther research on differences in paracetamol pharmacokinetics between ICU and MCU patients is warranted, as these differences might result in differences in efficacy. Furthermore, administration of paracetamol i.v. as potential cause of hypotension in the critically ill patient must not be overlooked.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.