ArticlePloS one2010
Time-dependent c-Myc transactomes mapped by Array-based nuclear run-on reveal transcriptional modules in human B cells.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Pontin Acts as a Potential Biomarker for Poor Clinical Outcome and Promotes Tumor Invasion in Hilar Cholangiocarcinoma.BioMed research international · 2018Trial
- CRISPR/Cas9 screen for genome-wide interrogation of essential MYC-bound E-boxes in cancer cells.Molecular oncology · 2023Article
- Losing CD45 and various B-cell markers in a case of MYC-driven pediatric high-grade B-cell lymphoma, not otherwise specified that transformed from Burkitt's lymphoma during rituximab-containing treatments: a case report.Virchows Archiv : an international journal of pathology · 2023Article
- Article
- STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells.European journal of immunology · 2016Article
- Interference with nuclear factor kappaB signaling pathway by pathogen-encoded proteases: global and selective inhibition.Molecular microbiology · 2016Review
- Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells.Cell communication and signaling : CCS · 2014Article
- Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis.Nature · 2014Article
- MYC and the art of microRNA maintenance.Cold Spring Harbor perspectives in medicine · 2014Review
- Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling.Cancer management and research · 2014Review
- NF-κB and CREB are required for angiotensin II type 1 receptor upregulation in neurons.PloS one · 2013Article
- Article
- Array-based nuclear run-on analysis.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Overexpression of the c-myc oncogene inhibits nonsense-mediated RNA decay in B lymphocytes.The Journal of biological chemistry · 2011Article
- Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene.The American journal of pathology · 2011Article
- Identification and regulation of c-Myb target genes in MCF-7 cells.BMC cancer · 2011Article
- Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation.PloS one · 2011Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe definition of transcriptional networks through measurements of changes in gene expression profiles and mapping of transcription factor binding sites is limited by the moderate overlap between binding and gene expression changes and the inability to directly measure global nuclear transcription (coined "transactome"). METHODOLOGY/PRINCIPAL
findingsWe developed a method to measure nascent nuclear gene transcription with an Array-based Nuclear Run-On (ANRO) assay using commercial microarray platforms. This strategy provides the missing component, the transactome, to fully map transcriptional networks. ANRO measurements in an inducible c-Myc expressing human P493-6 B cell model reveals time-dependent waves of transcription, with a transactome early after c-Myc induction that does not persist at a late, steady-state phase, when genes that are regulated by c-Myc and E2F predominate. Gene set matrix analysis further uncovers functionally related groups of genes putatively regulated by waves of transcription factor motifs following Myc induction, starting with AP1 and CREB that are followed by EGR1, NFkB and STAT, and ending with E2F, Myc and ARNT/HIF motifs. CONCLUSIONS/SIGNIFICANCE: By coupling ANRO with previous global mapping of c-Myc binding sites by chromatin immunoprecipitation (ChIP) in P493-6 cells, we define a set of transcriptionally regulated direct c-Myc target genes and pave the way for the use of ANRO to comprehensively map any transcriptional network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.