ArticleJournal of biomedicine & biotechnology2010
Enhanced muscle growth by plasmid-mediated delivery of myostatin propeptide.
Article in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Synergistically Acting on Myostatin and Agrin Pathways Increases Neuromuscular Junction Stability and Endurance in Old Mice.Aging and disease · 2024Article
- Characterization of tolloid-mediated cleavage of the GDF8 procomplex.The Biochemical journal · 2021Article
- A Novel Nanobody Directed against Ovine Myostatin to Enhance Muscle Growth in Mouse.Animals : an open access journal from MDPI · 2020Article
- Article
- Neonatal Systemic AAV-Mediated Gene Delivery of GDF11 Inhibits Skeletal Muscle Growth.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Maltose binding protein-fusion enhances the bioactivity of truncated forms of pig myostatin propeptide produced in E. coli.PloS one · 2017Article
- Targeted Editing of Myostatin Gene in Sheep by Transcription Activator-like Effector Nucleases.Asian-Australasian journal of animal sciences · 2016Article
- Functional verification of a porcine myostatin propeptide mutant.Transgenic research · 2015Article
- Over-Expression of Porcine Myostatin Missense Mutant Leads to A Gender Difference in Skeletal Muscle Growth between Transgenic Male and Female Mice.International journal of molecular sciences · 2015Article
- Pharmacology of manipulating lean body mass.Clinical and experimental pharmacology & physiology · 2015Review
- Ubiquitous Gasp1 overexpression in mice leads mainly to a hypermuscular phenotype.BMC genomics · 2012Article
- Role of TGF-β signaling in inherited and acquired myopathies.Skeletal muscle · 2011Article
- Production of bioactive rockfish (Sebastes schlegeli) myostatin-1 prodomain in an Escherichia coli system.The protein journal · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myostatin is a member of the transforming growth factor beta (TGF-beta) superfamily that functions as a negative regulator of skeletal muscle development and growth. Myostatin blockade therefore offers a strategy for promoting muscle growth in livestock production without resorting to genetic manipulation. In this report, we examined the effect of myostatin inhibition by plasmid-mediated delivery of a mutant myostatin propeptide (MProD76A), a natural inhibitor of myostatin, on the growth performance of mice. A significant increase in skeletal muscle mass was observed after a single intramuscular injection of naked plasmid DNA encoding MProD76A into mice. Enhanced muscle growth occurred because of myofiber hypertrophy, but no cardiac muscle hypertrophy and organomegaly was observed in the mice after myostatin inhibition by plasmid-mediated MProD76A delivery. These results demonstrate a promising approach to enhancing muscle growth that warrants further investigation in domestic animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.