ArticleIndian journal of human genetics2008
Apolipoprotein E gene polymorphism and dyslipidaemia in adult Asian Indians: A population based study from Calcutta, India.
Article in Indian journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Genetic variants of APOE and CCR4 as determinants of myocardial infarction among type 2 diabetes patients: a South Indian case-control analysis.Molecular biology reports · 2026Article
- Sex-specific differences in the association between APOE genotype and metabolic syndrome among middle-aged and older rural Indians.Metabolism open · 2024Article
- Synergistic effects of ACE (I/D) and Apo E (Hha I) gene polymorphisms on obesity, fat mass, and blood glucose level among the adult Asian Indians: A population-based study from Calcutta, India.Indian journal of endocrinology and metabolism · 2013Article
- APOE, MTHFR, LDLR and ACE polymorphisms among Angami and Lotha Naga populations of Nagaland, India.Journal of community health · 2011Article
- Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load.Biodemography and social biology · 2011Article
- Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians.Journal of cardiovascular disease research · 2010Article
- Genetics of coronary artery disease - a clinician's perspective.Indian heart journalReview
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe study was aimed to determine the association of Apolipoprotein E (apo E) gene polymorphisms on lipid levels in Asian Indian population.
methodsA total of 350 (184 males and 166 females) adult (30 years and above) Asian Indians of Calcutta and suburb participated in the study. Anthropometric measures, lipids profiles, and blood glucose measures were collected. Out of 350 subjects, a sample of 70 individuals was selected randomly for genotyping after adjusting for age and sex. The apo E gene polymorphisms were determined by agarose gel electrophoresis.
resultsThe apo E polymorphism showed significant association with dyslipidaemia (P=0.0135) with epsilon3/4 combination has had the highest occurrence of dyslipidaemia and metabolic syndrome (MS) followed by epsilon4/4 <epsilon3/3 <epsilon2/4 <epsilon2/3 in decreasing order.
conclusionsThe epsilon4 allele of apo E gene independent of other risk factors is associated with dyslipidaemia in particular with low HDLc and high TC: HDLc ratio.
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