ReviewNature reviews. Neuroscience2010
Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches.
Review in Nature reviews. Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 197 citations in OpenAlex.
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- Combined statistical-biophysical modeling links ion channel genes to physiology of cortical neuron types.Patterns (New York, N.Y.) · 2025Article
- Cell and tissue reprogramming: Unlocking a new era in medical drug discovery.Pharmacological reviews · 2025Review
- Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory.Communications biology · 2025Article
- Setting a double-capacitive neuron coupled with Josephson junction and piezoelectric source.Cognitive neurodynamics · 2024Article
- Memristor-based model of neuronal excitability and synaptic potentiation.Frontiers in neuroscience · 2024Article
- Article
- Heterogeneous off-target impact of ion-channel deletion on intrinsic properties of hippocampal model neurons that self-regulate calcium.Frontiers in cellular neuroscience · 2023Article
- Noise-induced collective dynamics in the small-world network of photosensitive neurons.Journal of biological physics · 2022Article
- Dendritic spine morphology regulates calcium-dependent synaptic weight change.The Journal of general physiology · 2022Article
- A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex.Nature communications · 2022Article
- Computational analysis of memory consolidation following inhibitory avoidance (IA) training in adult and infant rats: Critical roles of CaMKIIα and MeCP2.PLoS computational biology · 2022Article
- Autoregulation of switching behavior by cellular compartment size.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Microbes, metabolites and (synaptic) malleability, oh my! The effect of the microbiome on synaptic plasticity.Biological reviews of the Cambridge Philosophical Society · 2022Review
- A computational model of dopaminergic modulation of hippocampal Schaffer collateral-CA1 long-term plasticity.Journal of computational neuroscience · 2022Article
- A Modular Workflow for Model Building, Analysis, and Parameter Estimation in Systems Biology and Neuroscience.Neuroinformatics · 2022Article
- Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia-A Focus on Tyrosine Hydroxylase Deficiency.Journal of personalized medicine · 2021Review
- From synapse to network: models of information storage and retrieval in neural circuits.Current opinion in neurobiology · 2021Review
- Stable continual learning through structured multiscale plasticity manifolds.Current opinion in neurobiology · 2021Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Synaptic plasticity is thought to underlie learning and memory, but the complexity of the interactions between the ion channels, enzymes and genes that are involved in synaptic plasticity impedes a deep understanding of this phenomenon. Computer modelling has been used to investigate the information processing that is performed by the signalling pathways involved in synaptic plasticity in principal neurons of the hippocampus, striatum and cerebellum. In the past few years, new software developments that combine computational neuroscience techniques with systems biology techniques have allowed large-scale, kinetic models of the molecular mechanisms underlying long-term potentiation and long-term depression. We highlight important advancements produced by these quantitative modelling efforts and introduce promising approaches that use advancements in live-cell imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.