Evidence map›Paper›PMID 20300089›Full record

ReviewNature reviews. Genetics2010

Chromatin structure and the inheritance of epigenetic information.

Raphaël Margueron, Danny Reinberg

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 391 papers.

0numbers the graph read from it
0cells of the map it votes in
391citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

391 citing papers in PubMed.

  1. Article
  2. Article
  3. Epigenetic regulation of kidney development.Nature reviews. Nephrology · 2026
    Review
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  14. Review
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331 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Raphaël MargueronHoward Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, 522 First Avenue, New York, New York 10016, USA.
Danny Reinberg

Funding

Initiation of Transcription of Protein Coding GenesR37GM037120 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI REINBERG, DANNY · 2004 to 2013
$4.5M
Transcription Regulation by NC2R01GM064844 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI REINBERG, DANNY · 2002 to 2014
$3.3M
Howard Hughes Medical InstituteNIGMS NIH HHS 4R37GM037120NIGMS NIH HHS R01 GM064844NIGMS NIH HHS R01GM064844NIGMS NIH HHS R37 GM037120
6 · The paper itself

Abstract

Although it is widely accepted that the regulation of the chromatin landscape is pivotal to conveying the epigenetic program, it is still unclear how a defined chromatin domain is reproduced following DNA replication and transmitted from one cell generation to the next. Here, we review the multiple mechanisms that potentially affect the inheritance of epigenetic information in somatic cells. We consider models of how histones might be recycled following replication, and discuss the importance of positive-feedback loops, long-range gene interactions and the complex network of trans-acting factors in the transmission of chromatin states.

Indexed as

Epigenesis, GeneticAnimalsChromatinDNA ReplicationFeedback, PhysiologicalHistonesHumansModels, GeneticRNA, UntranslatedChromatinHistonesRNA, Untranslated

Identifiers

PMID20300089
PMCPMC3760772

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.