ArticleObesity (Silver Spring, Md.)2010
Adiposity and β-cell function: relationships differ with ethnicity and age.
Article in Obesity (Silver Spring, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- A Systematic Review of Beta Cell Function in Adults of Black African Ethnicity.Journal of diabetes research · 2019Pooled it
- Effects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Trial
- The impact of a low-carbohydrate (vs. low-fat) diet on fat mass loss in African American women is modulated by insulin sensitivity.Obesity (Silver Spring, Md.) · 2025Trial
- Increased β-Cell Responsivity Independent of Insulin Sensitivity in Healthy African American Adults.The Journal of clinical endocrinology and metabolism · 2020Trial
- Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity.The Journal of clinical endocrinology and metabolism · 2025Article
- Genetic Risk Phenotypes for Type 2 Diabetes Differ with Ancestry in US Adults with Diabetes and Overweight/Obesity.Archives of medical research · 2025Article
- Proinsulin-to-C-Peptide Ratio as a Marker of β-Cell Function in African American and European American Adults.Diabetes care · 2023Article
- Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin.Biology · 2022Article
- Minimal and Maximal Models to Quantitate Glucose Metabolism: Tools to Measure, to Simulate and to Run in Silico Clinical Trials.Journal of diabetes science and technology · 2022Article
- Insulin sensitivity and kinetics in African American and White people with obesity: Insights from different study protocols.Obesity (Silver Spring, Md.) · 2022Article
- Preintervention Clinical Determinants and Measured β-Cell Function As Predictors of Type 2 Diabetes Remission After Roux-en-Y Gastric Bypass Surgery.Diabetes care · 2021Article
- β-cell function in black South African women: exploratory associations with insulin clearance, visceral and ectopic fat.Endocrine connections · 2021Article
- Maternal undernutrition and offspring sex determine birth-weight, postnatal development and meat characteristics in traditional swine breeds.Journal of animal science and biotechnology · 2018Article
- Hepatic but Not Extrahepatic Insulin Clearance Is Lower in African American Than in European American Women.Diabetes · 2017Article
- Obstacles to Translating Genotype-Phenotype Correlates in Metabolic Disease.Physiology (Bethesda, Md.) · 2017Review
- Association of late-night carbohydrate intake with glucose tolerance among pregnant African American women.Maternal & child nutrition · 2016Article
- Multiple Healthful Dietary Patterns and Type 2 Diabetes in the Women's Health Initiative.American journal of epidemiology · 2016Article
- Baseline insulin sensitivity affects response to high-amylose maize resistant starch in women: a randomized, controlled trial.Nutrition & metabolism · 2016Article
- Racial/Ethnic Differences in Insulin Resistance and Beta Cell Function: Relationship to Racial Disparities in Type 2 Diabetes among African Americans versus Caucasians.Current obesity reports · 2015Review
- The oral minimal model method.Diabetes · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The prevalence of type 2 diabetes is higher among African Americans (AA) vs. European Americans (EA), is highest at middle age, and is related to obesity. This study was conducted to test the hypothesis that the association of adiposity (percent body fat (%fat)) with indexes of insulin sensitivity (S(I)) and β-cell function would differ with ethnicity and age. Subjects were 168 healthy, normoglycemic AA and EA girls and women aged 7-12 years, 18-32 years, and 40-70 years. An intravenous glucose tolerance test (IVGTT) was used to assess indexes of insulin secretion and action: S(I), acute C-peptide secretion (X0); basal, first-phase, second-phase, and total β-cell responsivity to glucose (PhiB, Phi1, Phi2, and Phi(TOT), respectively); and the disposition index (DI = S(I) × Phi(TOT)). %Fat was assessed with dual energy X-ray absorptiometrys. Adiposity was significantly associated with S(I) among EA (-0.57, P < 0.001) but not AA (-0.20, P = 0.09). Adiposity appeared stimulatory to β-cell function in the two groups of younger subjects and in EA, but inhibitory in postmenopausal women, particularly AA postmenopausal women. Among AA postmenopausal women, %fat was inversely associated with Phi1 (r = -0.57, P < 0.05) and Phi(TOT) (r = -0.68, P < 0.01). These results suggest that the impact of adiposity on insulin secretion and action differs with age and ethnicity.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.