ArticleDiabetes2010
Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
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- Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025Review
- Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications.Signal transduction and targeted therapy · 2023Review
- High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells.Molecular medicine reports · 2021Article
- Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload.BMC biology · 2021Article
- Neural crest-specific deletion ofDisease models & mechanisms · 2021Article
- Dietary Intervention With α-Amylase Inhibitor in White Kidney Beans Added Yogurt Modulated Gut Microbiota to Adjust Blood Glucose in Mice.Frontiers in nutrition · 2021Article
- Transcriptomic responses of hypothalamus to acute exercise in type 2 diabetic Goto-Kakizaki rats.PeerJ · 2019Article
- TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress.Aging cell · 2018Article
- The role of DNA-PK in aging and energy metabolism.The FEBS journal · 2018Review
- Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance.Nutrients · 2017Review
- DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.Cell metabolism · 2017Article
- Normalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regression.Cardiovascular research · 2016Article
- Article
- Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats.Diabetologia · 2015Article
- Resveratrol improves high-fat diet induced insulin resistance by rebalancing subsarcolemmal mitochondrial oxidation and antioxidantion.Journal of physiology and biochemistry · 2015Article
- The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction.The Journal of physiology · 2014Article
- Article
- Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles.BioMed research international · 2014Article
- FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice.Diabetes · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAlthough advanced age is a risk factor for type 2 diabetes, a clear understanding of the changes that occur during middle age that contribute to the development of skeletal muscle insulin resistance is currently lacking. Therefore, we sought to investigate how middle age impacts skeletal muscle fatty acid handling and to determine how this contributes to the development of diet-induced insulin resistance. RESEARCH DESIGN AND
methodsWhole-body and skeletal muscle insulin resistance were studied in young and middle-aged wild-type and CD36 knockout (KO) mice fed either a standard or a high-fat diet for 12 weeks. Molecular signaling pathways, intramuscular triglycerides accumulation, and targeted metabolomics of in vivo mitochondrial substrate flux were also analyzed in the skeletal muscle of mice of all ages.
resultsMiddle-aged mice fed a standard diet demonstrated an increase in intramuscular triglycerides without a concomitant increase in insulin resistance. However, middle-aged mice fed a high-fat diet were more susceptible to the development of insulin resistance-a condition that could be prevented by limiting skeletal muscle fatty acid transport and excessive lipid accumulation in middle-aged CD36 KO mice.
conclusionOur data provide insight into the mechanisms by which aging becomes a risk factor for the development of insulin resistance. Our data also demonstrate that limiting skeletal muscle fatty acid transport is an effective approach for delaying the development of age-associated insulin resistance and metabolic disease during exposure to a high-fat diet.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.