Trial reportAJNR. American journal of neuroradiology2010
Wallerian degeneration in the corticospinal tract evaluated by diffusion tensor imaging correlates with motor deficit 30 days after middle cerebral artery ischemic stroke.
Trial report in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01862172 (FOCAL CORTICAL ATROPHY AFTER MYOCARDIAL INTERNAL CAPSULE), which is not on this map. Cited by 103 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Focal cortical atrophy after myocardial internal capsule: correlation fraction anisotropy beam pyramid and disability
Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it, 181 citations in OpenAlex.
- Research hotspots and trends in the application of diffusion tensor imaging in ischemic stroke: a bibliometric analysis (2003-2024).Frontiers in neurology · 2025Pooled it
- Changes in synaptic density in the subacute phase after ischemic stroke: AJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Trial
- Stronger prediction of motor recovery and outcome post-stroke by cortico-spinal tract integrity than functional connectivity.PloS one · 2018Trial
- Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study.Scientific reports · 2017Trial
- Does stroke location predict walk speed response to gait rehabilitation?Human brain mapping · 2016Trial
- Deep grey nuclei automated assessment in acute-subacute phase of middle cerebral artery cortical stroke helps predict the 3-month outcome.Brain imaging and behavior · 2026Article
- The relationship between corticospinal tract and the affected lower limb function and walking ability in subacute stroke patients: a preliminary study.Journal of physical therapy science · 2026Article
- Analysis of recovery-related white matter microstructures in visual spatial neglect based on diffusion tensor imaging.Brain imaging and behavior · 2026Article
- Histopathological Changes of the Corticospinal Tract Following Hemorrhagic and Ischemic Stroke.Brain sciences · 2025Article
- Regional Hypoperfusion Predicts White Matter Tract Degeneration in Recent Single Subcortical Infarcts.Journal of the American Heart Association · 2025Article
- Association Between Changes in White Matter Volume Detected With Diffusion Tensor-Based Morphometry and Motor Recovery After Stroke.Neurology · 2025Article
- Loss of Sarm1 Mitigates Axonal Degeneration and Promotes Neuronal Repair After Ischemic Stroke.bioRxiv : the preprint server for biology · 2025Article
- Associations between structural injury and task-based corticomuscular connectivity after stroke.Frontiers in neurology · 2025Article
- Microstructure of the residual corticofugal projection from primary motor cortex in chronic stroke.Brain communications · 2025Article
- Article
- Stroke-Induced Secondary Neurodegeneration of the Corticospinal Tract-Time Course and Mechanisms Underlying Signal Changes in Conventional and Advanced Magnetic Resonance Imaging.Journal of clinical medicine · 2024Review
- Visualizing Wallerian degeneration in the corticospinal tract after sensorimotor cortex ischemia in mice.Neural regeneration research · 2024Article
- Integrative Approaches in Acute Ischemic Stroke: From Symptom Recognition to Future Innovations.Biomedicines · 2023Review
- Role of NADCellular and molecular neurobiology · 2023Review
- Neural bases characterizing chronic and severe upper-limb motor deficits after brain lesion.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe quantification and clinical significance of WD in CSTs following supratentorial stroke are not well understood. We evaluated the anisotropy by using DTI and signal-intensity changes on conventional MR imaging in the CST to determine whether these findings are correlated with limb motor deficit in patients with MCA ischemic stroke. MATERIALS AND
methodsWe studied 60 patients within 12 hours of stroke onset. At admission, day 3, and day 30 of evolution, patients underwent multimodal MR imaging, including DTI sequences. We assessed the severity of limb weakness by using the motor subindex scores (5a, 5b, 6a, 6b) of the m-NIHSS and established 3 groups: I (m-NIHSS scores of 0), II (m-NIHSS, 1-4), and III (m-NIHSS, 5-8). FA values and rFAs were measured on the affected and the unaffected CSTs in the pons.
resultsFA values for the CST were significantly lower on the affected side compared with the unaffected side only at day 30 (P < .001), and the rFA was significantly correlated with the motor deficit at day 30 (P < .001; r = -0.793). The sensitivity, specificity, and positive and negative predictive values for motor deficit by rFA < 0.925 were 95.2%, 94.9%, 90.9%, and 97.4%, respectively.
conclusionsWD in the CST revealed by DTI correlates with motor deficit 30 days after MCA ischemic stroke. This study highlights the utility of imaging follow-up at 30 days and the potential of DTI as a surrogate marker in clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.