ArticleAJNR. American journal of neuroradiology2010
JC virus infection of the brain.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 134 citations in OpenAlex.
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- JC virus spread is potentiated by glial replication and demyelination-linked glial proliferation.Brain : a journal of neurology · 2024Article
- A rare case of progressive multifocal leukoencephalopathy.Radiology case reports · 2024Article
- John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis.Diseases (Basel, Switzerland) · 2024Review
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- MRI characteristics of chemotherapy-related central neurotoxicity: a pictorial review.Insights into imaging · 2024Review
- Anything but Little: a Pictorial Review on Anatomy and Pathology of the Cerebellum.Clinical neuroradiology · 2023Review
- CNS Involvement of DLBCL Presenting with an Unusual Non-Enhancing Infiltrative Mass.Diagnostics (Basel, Switzerland) · 2023Article
- Presumptive Progressive Multifocal Encephalopathy in an Immunocompetent Patient: A Rare Case Report.Cureus · 2023Article
- Lymphomas of Central Nervous System.Advances in experimental medicine and biology · 2023Article
- Changes in Brain Volumes Are Relevant during Natalizumab-Associated Progressive Multifocal Leukoencephalopathy: Lessons from a Case Report.International journal of molecular sciences · 2022Article
- CD8 Encephalitis: A Diagnostic Dilemma.Diagnostics (Basel, Switzerland) · 2022Article
- Methotrexate induced neurotoxicity in a patient with rheumatoid arthritis on rituximab therapy: a case-based review.Rheumatology international · 2022Review
- Understanding progressive multifocal leukoencephalopathy: links between milky-way appearance and mismatch T2/FLAIR.The neuroradiology journal · 2021Article
- The neurological sequelae of pandemics and epidemics.Journal of neurology · 2021Review
- Four cases of progressive multifocal leukoencephalopathy in iatrogenic immunocompromised patients.eNeurologicalSci · 2020Article
- CNS Infections in Immunoincompetent Patients : Neuroradiological and Clinical Features.Clinical neuroradiology · 2020Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since its initial description, there have been significant changes in the epidemiology, pathogenesis, and clinical and imaging manifestations of JCV infection of brain. The most common clinical manifestation is PML. Other recently described CNS manifestations are JCE, JCVGCN, and JCM. Although AIDS is the most common predisposing factor for JCV reactivation, there is increasing incidence of brain manifestations of JCV reactivation in non-HIV settings, including different rheumatologic, hematologic, and oncologic conditions; monoclonal antibody therapy; transplant recipients; primary immunodeficiency syndromes; and even in patients without any recognizable immune deficiency. IRIS may develop secondary to restoration of immunity in HIV-positive patients with PML receiving antiretroviral therapy. This is of profound clinical significance and needs to be diagnosed promptly. Imaging plays a crucial role in the diagnosis of the disease, monitoring of treatment response, identifying disease progression, and predicting prognosis. In this article, current understanding of the epidemiology, pathogenesis, clinical presentations, and all aspects of imaging of JCV infection of the brain have been comprehensively reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.