ArticleClinical journal of the American Society of Nephrology : CJASN2010
Examination of association with candidate genes for diabetic nephropathy in a Mexican American population.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 42 citations in OpenAlex.
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- Comprehensive Analysis ofGenes · 2022Article
- Association between engulfment and cell motility 1-gene polymorphisms and diabetic nephropathy in an Egyptian population with type 2 diabetes.Journal of diabetes and metabolic disorders · 2022Article
- The association between weight-adjusted-waist index and increased urinary albumin excretion in adults: A population-based study.Frontiers in nutrition · 2022Article
- Urinary Carnosinase-1 Excretion is Associated with Urinary Carnosine Depletion and Risk of Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Cohort Study.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- The single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2020Article
- Understanding the growing epidemic of type 2 diabetes in the Hispanic population living in the United States.Diabetes/metabolism research and reviews · 2019Review
- Serum Carnosinase-1 and Albuminuria Rather than theJournal of diabetes research · 2019Article
- Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy in Malaysian Type 2 Diabetic Patients.International journal of chronic diseases · 2019Article
- The (CTG)The Indian journal of medical research · 2016Article
- High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Recent progress in the genetics of diabetic microvascular complications.World journal of diabetes · 2015Review
- Family-based association analysis: a fast and efficient method of multivariate association analysis with multiple variants.BMC bioinformatics · 2015Article
- Association between ELMO1 gene polymorphisms and diabetic nephropathy in an Iranian population.Journal of diabetes and metabolic disorders · 2015Article
- Single nucleotide polymorphisms for feed efficiency and performance in crossbred beef cattle.BMC genetics · 2014Article
- Susceptibility gene search for nephropathy and related traits in Mexican-Americans.Molecular biology reports · 2013Review
- Association of ELMO1 gene polymorphisms with diabetic nephropathy in Chinese population.Journal of endocrinological investigation · 2013Article
- Diabetic nephropathy among Mexican Americans.Clinical nephrology · 2012Review
- Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
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12 authors at 6 institutions in 1 country.
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Abstract
BACKGROUND AND
objectivesDiabetic nephropathy (DN) is a multifactorial complication characterized by persistent proteinuria in susceptible individuals with type 1 and type 2 diabetes. Disease burden in people of Mexican-American descent is particularly high, but there are only a few studies that characterize genes for DN in this ethnic group. Two genes, carnosine dipeptidase 1 (CNDP1) and engulfment and cell motility 1 (ELMO1) previously showed association with DN in other ethnic groups. CNDP1 and ELMO1 were examined along with eight other genes that are less well characterized for DN in a new study of Mexican-Americans. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The target sample was patients of Mexican-American ancestry collected from three centers: 455 patients with DN and 437 controls with long-term diabetes but no incident nephropathy. Forty-two, 227, and 401 single nucleotide polymorphisms (SNPs) in CNDP1, ELMO1, and the other eight genes, respectively, were examined.
resultsNo region in CNDP1 or ELMO1 showed significant P values. Of the other eight candidate genes, an association of DN with a SNP pair, rs2146098 and rs6659783, was found in hemicentin 1 (HMCN1) (unadjusted P = 6.1 x 10(-5)). Association with a rare haplotype in this region was subsequently identified.
conclusionsThe associations in CNDP1 or ELMO1 were not replicable; however, an association of DN with HMCN1 was found. Additional work at this and other loci will enable refinement of the genetic hypotheses regarding DN in the Mexican-American population to find therapies for this debilitating disease.
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