ReviewCurrent opinion in neurobiology2010
Re-valuing the amygdala.
Review in Current opinion in neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
160 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of human prediction error for incentives, perception, cognition, and action.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy.Translational psychiatry · 2013Pooled it
- Opposing neural effects of naltrexone on food reward and aversion: implications for the treatment of obesity.Psychopharmacology · 2014Trial
- No laughing matter: intranasal oxytocin administration changes functional brain connectivity during exposure to infant laughter.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- The influence of serotonin on fear learning.PloS one · 2012Trial
- Pregabalin influences insula and amygdala activation during anticipation of emotional images.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Causal Dynamics of Social Gaze in Primate Prefrontal-Amygdala Networks Revealed by Dynamic Bayesian Modeling.Nature communications · 2026Article
- Contributions of the basolateral amygdala and nucleus accumbens to sustaining not just initiating cognitive effort.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Psilocybin Attenuates Cortical Representations of Aversion in the Mouse Auditory Cortex.bioRxiv : the preprint server for biology · 2026Article
- Risk reshapes amygdala representation of choice.bioRxiv : the preprint server for biology · 2025Article
- Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.Cell reports · 2025Article
- Context flexibly modulates cue representations in visual cortex.Nature communications · 2025Article
- Robust memory of face moral values is encoded in the human caudate tail: a simultaneous EEG-fMRI study.Scientific reports · 2024Article
- The amygdala and the pursuit of future rewards.Frontiers in neuroscience · 2024Review
- Characterization of oxytocin and vasopressin receptors in the Southern giant pouched rat and comparison to other rodents.Frontiers in endocrinology · 2024Article
- Memory Storage in Distributed Engram Cell Ensembles.Advances in neurobiology · 2024Review
- Induction of Anxiety-Like Phenotypes by Knockdown of Cannabinoid Type-1 Receptors in the Amygdala of Marmosets.Neuroscience bulletin · 2023Article
- Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters.Psychopharmacology · 2023Article
- Identification of central amygdala and trigeminal motor nucleus connectivity in humans: An ultra-high field diffusion MRI study.Human brain mapping · 2023Article
- Optogenetic stimulation in the medial prefrontal cortex modulates stimulus valence from rewarding and aversive to neutral states.Frontiers in psychiatry · 2023Article
100 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Recent advances indicate that the amygdala represents valence: a general appetitive/aversive affective characteristic that bears similarity to the neuroeconomic concept of value. Neurophysiological studies show that individual amygdala neurons respond differentially to a range of stimuli with positive or negative affective significance. Meanwhile, increasingly specific lesion/inactivation studies reveal that the amygdala is necessary for processes--for example, fear extinction and reinforcer devaluation--that involve updating representations of value. Furthermore, recent neuroimaging studies suggest that the human amygdala mediates performance on many reward-based decision-making tasks. The encoding of affective significance by the amygdala might be best described as a representation of state value-a representation that is useful for coordinating physiological, behavioral, and cognitive responses in an affective/emotional context.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.