ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2010
Developing a national strategy to prevent dementia: Leon Thal Symposium 2009.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Alzheimer's disease - the journey of a healthy brain into organ failure.Molecular neurodegeneration · 2022Review
- Disease-Modifying Therapies for Alzheimer's Disease: More Questions than Answers.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities.Oncotarget · 2016Article
- A Late Life Risk Index for Severe Cognitive Impairment in Mexico.Journal of Alzheimer's disease : JAD · 2016Article
- Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- Was phenserine a failure or were investigators mislead by methods?Current Alzheimer research · 2012Article
- Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2012Article
- Structural imaging in early pre-states of dementia.Biochimica et biophysica acta · 2012Review
- Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments.Journal of Alzheimer's disease : JAD · 2011Review
- Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials.Alzheimer's research & therapy · 2010Article
- Predicting Cognitive Decline and Dementia with the Newly Normed SKT Short Cognitive Performance Test.Dementia and geriatric cognitive disorders extraArticle
- Alzheimer Disease Worries, Fears, and Stigma and Their Relationship to Genetic and Interventional Research Engagement.Alzheimer disease and associated disordersArticle
- Community engagement in diverse populations for Alzheimer disease prevention trials.Alzheimer disease and associated disordersArticle
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Authors and funding
36 authors.
Funding
Abstract
Among the major impediments to the design of clinical trials for the prevention of Alzheimer's disease (AD), the most critical is the lack of validated biomarkers, assessment tools, and algorithms that would facilitate identification of asymptomatic individuals with elevated risk who might be recruited as study volunteers. Thus, the Leon Thal Symposium 2009 (LTS'09), on October 27-28, 2009 in Las Vegas, Nevada, was convened to explore strategies to surmount the barriers in designing a multisite, comparative study to evaluate and validate various approaches for detecting and selecting asymptomatic people at risk for cognitive disorders/dementia. The deliberations of LTS'09 included presentations and reviews of different approaches (algorithms, biomarkers, or measures) for identifying asymptomatic individuals at elevated risk for AD who would be candidates for longitudinal or prevention studies. The key nested recommendations of LTS'09 included: (1) establishment of a National Database for Longitudinal Studies as a shared research core resource; (2) launch of a large collaborative study that will compare multiple screening approaches and biomarkers to determine the best method for identifying asymptomatic people at risk for AD; (3) initiation of a Global Database that extends the concept of the National Database for Longitudinal Studies for longitudinal studies beyond the United States; and (4) development of an educational campaign that will address public misconceptions about AD and promote healthy brain aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.