ArticleCancer cell international2010
A cancer derived mutation in the retinoblastoma gene with a distinct defect for LXCXE dependent interactions.
Article in Cancer cell international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Correlation between FamilyDisease markers · 2021Article
- APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway.Bioscience reports · 2016Review
- Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization.eLife · 2013Article
- Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma.The Journal of clinical investigation · 2012Review
- Analysis of cell cycle position in mammalian cells.Journal of visualized experiments : JoVE · 2012Article
- RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control.Molecular cell · 2011Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe interaction between viral oncoproteins such as Simian virus 40 TAg, adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB) occurs through a well characterized peptide sequence, LXCXE, on the viral protein and a well conserved groove in the pocket domain of pRB. Cellular proteins, such as histone deacetylases, also use this mechanism to interact with the retinoblastoma protein to repress transcription at cell cycle regulated genes. For these reasons this region of the pRB pocket domain is thought to play a critical role in growth suppression.
resultsIn this study, we identify and characterize a tumor derived allele of the retinoblastoma gene (RB1) that possesses a discrete defect in its ability to interact with LXCXE motif containing proteins that compromises proliferative control. To assess the frequency of similar mutations in the RB1 gene in human cancer, we screened blood and tumor samples for similar alleles. We screened almost 700 samples and did not detect additional mutations, indicating that this class of mutation is rare.
conclusionsOur work provides proof of principal that alleles encoding distinct, partial loss of function mutations in the retinoblastoma gene that specifically lose LXCXE dependent interactions, are found in human cancer.
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Registered trials
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