ArticleBMC medical genetics2010
EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Event-related Oscillations to Emotional Faces are Related to a History of Internalizing Disorders.Clinical EEG and neuroscience · 2023Article
- Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk.Behavioral sciences (Basel, Switzerland) · 2020Article
- Temporal stability of posterior EEG alpha over twelve years.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
- Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- Event-related oscillations (ERO) during an active discrimination task: Effects of lesions of the nucleus basalis magnocellularis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2016Article
- Low voltage alpha EEG phenotype is associated with reduced amplitudes of alpha event-related oscillations, increased cortical phase synchrony, and a low level of response to alcohol.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2015Article
- Genetic psychophysiology: advances, problems, and future directions.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2014Review
- Cholinergic modulation of event-related oscillations (ERO).Brain research · 2014Article
- CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2014Article
- Evidence for a genetic component for substance dependence in Native Americans.The American journal of psychiatry · 2013Review
- Event-related oscillations to affective stimuli: heritability, linkage and relationship to externalizing disorders.Journal of psychiatric research · 2012Article
- Linkage analyses of stimulant dependence, craving, and heavy use in American Indians.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Genome-wide scan for self-rating of the effects of alcohol in American Indians.Psychiatric genetics · 2010Article
- Changes of the brain's bioelectrical activity in cognition, consciousness, and some mental disorders.Medical journal of the Islamic Republic of IranReview
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4 authors.
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Abstract
backgroundEvidence for a high degree of heritability of EEG alpha phenotypes has been demonstrated in twin and family studies in a number of populations. However, information on linkage of this phenotype to specific chromosome locations is still limited. This study's aims were to map loci linked to EEG alpha phenotypes and to determine if there was overlap with loci previously mapped for alcohol dependence in an American Indian community at high risk for substance dependence.
methodsEach participant gave a blood sample and completed a structured diagnostic interview using the Semi Structured Assessment for the Genetics of Alcoholism. Bipolar EEGs were collected and spectral power determined in the alpha (7.5-12.0 Hz) frequency band for two composite scalp locations previously identified by principal components analyses (bilateral fronto-central and bilateral centro-parietal-occipital). Genotypes were determined for a panel of 791 micro-satellite polymorphisms in 410 members of multiplex families using SOLAR.
resultsSixty percent of this study population had a lifetime diagnosis of alcohol dependence. Analyses of multipoint variance component LOD scores, for the EEG alpha power phenotype, revealed two loci that had a LOD score of 3.0 or above for the fronto-central scalp region on chromosomes 1 and 6. Additionally, 4 locations were identified with LOD scores above 2.0 on chromosomes 4, 11, 14, 16 for the fronto-central location and one on chromosome 2 for the centro-parietal-occipital location.
conclusionThese results corroborate the importance of regions on chromosome 4 and 6 highlighted in prior segregation studies in this and other populations for alcohol dependence-related phenotypes, as well as other areas that overlap with other substance dependence phenotypes identified in previous linkage studies in other populations. These studies additionally support the construct that EEG alpha recorded from fronto-central scalp areas may represent an important endophenotype associated with alcohol and other substance dependence.
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