ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2010
Panallergens and their impact on the allergic patient.
Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed.
- Microarray Analysis Confirms ImmunoCAP-Fluorescence Enzyme Immunoassay Results on Specific IgE in Patients with Atopic Dermatitis and Suspected Birch Pollen-Related Food Allergy.International archives of allergy and immunology · 2022Trial
- A Fully Automated Chemiluminescent Immunoassay for Component-Resolved Diagnosis of Pollen Allergy: Validation of Six CHORUS CLIA Assays.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- Tree pollen allergen sensitization: Prevalence, risk factors, and geographic variation in the United States.The journal of allergy and clinical immunology. Global · 2026Article
- Evolution of IgE sensitization profiles toThe World Allergy Organization journal · 2026Article
- In vitro IgE diagnostics in inhalant allergy: Plant and mold allergens.Allergologie select · 2026Review
- Association of allergen stability and epithelial barrier function in sensitized patients.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Article
- Update on hazelnut allergy: Allergen characterization, epidemiology, food processing technique and detecting strategy.Comprehensive reviews in food science and food safety · 2025Review
- Sensitization profiles to olive pollen allergens and allergic respiratory disease severity in patients from Jaén, Spain: A cross-sectional study.The World Allergy Organization journal · 2025Article
- Characterization of the clinical relevance and hypoallergenic peptides of the newly evidenced major allergen Hum j 1.Frontiers in immunology · 2025Article
- Can Physicochemical Properties Alter the Potency of Aeroallergens? Part 1 - Aeroallergen Protein Families.Current allergy and asthma reports · 2024Review
- Allergenic Potential of Common Hops (Nutrients · 2024Article
- Impact of Enolase in Allergic Disease.Current allergy and asthma reports · 2024Review
- Cross-Reactivity of Ragweed Pollen Calcium-Binding Proteins and IgE Sensitization in a Ragweed-Allergic Population from Western Romania.Advances in respiratory medicine · 2024Article
- Utilizing the Banana S-Adenosyl-L-Homocysteine Hydrolase Allergen to Identify Cross-Reactive IgE in Ryegrass-, Latex-, and Kiwifruit-Allergic Individuals.International journal of molecular sciences · 2024Article
- Detection of Bet v 1 Homologous Proteins and Plant Profilins by Indirect ELISA.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Revisiting Fruit Allergy: Prevalence across the Globe, Diagnosis, and Current Management.Foods (Basel, Switzerland) · 2023Review
- Perspectives of Proteomics in Respiratory Allergic Diseases.International journal of molecular sciences · 2023Review
- Sensitization patterns of plant panallergens in Georgian allergic population from the molecular perspective.Postepy dermatologii i alergologii · 2023Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The panallergen concept encompasses families of related proteins, which are involved in general vital processes and thus, widely distributed throughout nature. Plant panallergens share highly conserved sequence regions, structure, and function. They are responsible for many IgE cross-reactions even between unrelated pollen and plant food allergen sources. Although usually considered as minor allergens, sensitization to panallergens might be problematic as it bears the risk of developing multiple sensitizations. Clinical manifestations seem to be tightly connected with geographical and exposure factors. Future population- and disease-based screenings should provide new insights on panallergens and their contribution to disease manifestations. Such information requires molecule-based diagnostics and will be valuable for developing patient-tailored prophylactic and therapeutic approaches. In this article, we focus on profilins, non-specific lipid transfer proteins, polcalcins, and Bet v 1-related proteins and discuss possible consequences of panallergen sensitization for the allergic patient. Based on their pattern of IgE cross-reactivity, which is reflected by their distribution in the plant kingdom, we propose a novel classification of panallergens into ubiquitously spread "real panallergens" (e.g. profilins) and widespread "eurallergens" (e.g. polcalcins). "Stenallergens" display more limited distribution and cross-reactivity patterns, and "monallergens" are restricted to a single allergen source.
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Registered trials
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