ArticleEvolution; international journal of organic evolution2010
Promiscuity and the rate of molecular evolution at primate immunity genes.
Article in Evolution; international journal of organic evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Infectious disease and group size: more than just a numbers game.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Pooled it
- Evolutionary Complexity of Primate Immune System Uncovered by the Extensive Phylogenomic Sampling.Genome biology and evolution · 2026Article
- Gene Protein Sequence Evolution Can Predict the Rapid Divergence of Ovariole Numbers in the Drosophila melanogaster Subgroup.Genome biology and evolution · 2024Article
- Convergent rates of protein evolution identify novel targets of sexual selection in primates.Evolution; international journal of organic evolution · 2024Article
- Genes underlying the evolution of tetrapod testes size.BMC biology · 2021Article
- Contrasting patterns of molecular evolution in metazoan germ line genes.BMC evolutionary biology · 2019Article
- Sexual conflict and seminal fluid proteins: a dynamic landscape of sexual interactions.Cold Spring Harbor perspectives in biology · 2014Review
- Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance.The ISME journal · 2014Article
- Rates of evolution of hominoid seminal proteins are correlated with function and expression, rather than mating system.Journal of molecular evolution · 2014Article
- Immune anticipation of mating in Drosophila: Turandot M promotes immunity against sexually transmitted fungal infections.Proceedings. Biological sciences · 2013Article
- Sequence diversity of Pan troglodytes subspecies and the impact of WFDC6 selective constraints in reproductive immunity.Genome biology and evolution · 2013Article
- Article
- Evolutionary Modeling of Genotype-Phenotype Associations, and Application to Primate Coding and Non-coding mtDNA Rate Variation.Evolutionary bioinformatics online · 2013Article
- Functional primate genomics--leveraging the medical potential.Journal of molecular medicine (Berlin, Germany) · 2012Review
- Birth-and-death of KLK3 and KLK2 in primates: evolution driven by reproductive biology.Genome biology and evolution · 2012Article
- Is promiscuity associated with enhanced selection on MHC-DQα in mice (genus Peromyscus)?PloS one · 2012Article
- The molecular evolution of animal reproductive tract proteins: what have we learned from mating-system comparisons?International journal of evolutionary biology · 2011Article
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2 authors.
Funding
Abstract
Recently, a positive correlation between basal leukocyte counts and mating system across primates suggested that sexual promiscuity could be an important determinant of the evolution of the immune system. Motivated by this idea, we examined the patterns of molecular evolution of 15 immune defense genes in primates in relation to promiscuity and other variables expected to affect disease risk. We obtained maximum likelihood estimates of the rate of protein evolution for terminal branches of the primate phylogeny at these genes. Using phylogenetically independent contrasts, we found that immunity genes evolve faster in more promiscuous species, but only for a subset of genes that interact closely with pathogens. We also observed a significantly greater proportion of branches under positive selection in the more promiscuous species. Analyses of independent contrasts also showed a positive effect of group size. However, this effect was not restricted to genes that interact closely with pathogens, and no differences were observed in the proportion of branches under positive selection in species with small and large groups. Together, these results suggest that mating system has influenced the evolution of some immunity genes in primates, possibly due to increased risk of acquiring sexually transmitted diseases in species with higher levels of promiscuity.
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