ReviewEuropean journal of epidemiology1991
Fungal cell adhesion molecules in Candida albicans.
Review in European journal of epidemiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- A new perspective in sepsis treatment: could RGD-dependent integrins be novel targets?Drug discovery today · 2020Review
- New Aspects of Invasive Growth Regulation Identified by Functional Profiling of MAPK Pathway Targets inGenetics · 2020Article
- The haustorial transcriptome of the cucurbit pathogen Podosphaera xanthii reveals new insights into the biotrophy and pathogenesis of powdery mildew fungi.BMC genomics · 2019Article
- Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology.Expert opinion on drug delivery · 2015Article
- The Candida albicans Kar2 protein is essential and functions during the translocation of proteins into the endoplasmic reticulum.Current genetics · 2011Article
- Biochemical and immunological characterization of MP65, a major mannoprotein antigen of the opportunistic human pathogen Candida albicans.Infection and immunity · 2000Article
- Virulence factors of medically important fungi.Clinical microbiology reviews · 1996Review
- Fungal fimbriae are composed of collagen.The EMBO journal · 1996Article
- Purification and biochemical characterization of a 65-kilodalton mannoprotein (MP65), a main target of anti-Candida cell-mediated immune responses in humans.Infection and immunity · 1996Article
- Antibody response that protects against disseminated candidiasis.Infection and immunity · 1995Article
- Specific interaction of Aspergillus fumigatus with fibrinogen and its role in cell adhesion.Infection and immunity · 1994Article
- Is Pneumocystis carinii a deep mycosis-like agent?European journal of epidemiology · 1992Review
- Specific binding of human fibrinogen fragment D to Aspergillus fumigatus conidia.Infection and immunity · 1992Article
- Cytological immunodetection of yeast glycoprotein secretion.European journal of epidemiology · 1992Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adherence of Candida albicans to host tissues is considered a crucial step in the pathogenesis of candidiasis. Using in vitro assays, it was demonstrated that the yeast-mycelium transition was an important phenomenon in the acquisition of adhesive properties. Proteins with MWs of 60, 68, 200 and greater than 200 kDa seemed to be involved in germ tube adherence to plastic surfaces. Likewise, recent investigations have revealed that C. albicans expresses on its surface receptors which interact with a wide variety of host proteins, particularly some extracellular matrix components like fibronectin, laminin and collagen. Plasmatic components, such as fibrinogen, iC3b and C3d, have also been proposed as mediators of adherence of C. albicans. Thus, by their reaction with laminin, fibrinogen and C3d, the mannoproteins of 68 and 60 kDa demonstrated multiple biological activities. Proteins of similar MWs were detected as C3d and iC3b receptors, the latter showing similarities with the neutrophil CR3. Based upon the antigenic, structural and functional homologies between the candidal receptors and mammalian integrins, it was postulated that these fungal cell adhesion molecules (F-CAM) are members of the integrin family. Interactions with host proteins and molecular mimicry of mammalian adhesion molecules may be a fertile area for further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.