ArticleThe American journal of pathology1991
Specific binding of human low-density lipoprotein to the surface of schistosomula of Schistosoma mansoni and ingestion by the parasite.
Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Human growth factor-mediated signalling through lipid rafts regulates stem cell proliferation, development and survival ofOpen biology · 2024Article
- A bloody interaction: plasma proteomics reveals gilthead sea bream (Sparus aurata) impairment caused by Sparicotyle chrysophrii.Parasites & vectors · 2022Article
- HDL Receptor inFrontiers in cell and developmental biology · 2022Review
- Isoforms of Hsp70-binding human LDL in adult Schistosoma mansoni worms.Parasitology research · 2015Article
- Lipid and fatty acid compositions of a trematode, Isoparorchis hypselobagri Billet, 1898 (Digenea: Isoparorchiidae) infecting swim bladder of Wallago attu in the district North 24-Parganas of West Bengal.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Article
- Schistosome feeding and regurgitation.PLoS pathogens · 2014Review
- Modulation of paraoxonases during infectious diseases and its potential impact on atherosclerosis.Lipids in health and disease · 2012Review
- Scanning electron microscopy of the human low-density lipoprotein interaction with the tegument of Schistosoma mansoni.Parasitology research · 2011Article
- Major lipid classes and their fatty acids in a parasitic nematode, Ascaridia galli.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2010Article
- Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome.Progress in lipid research · 2010Review
- Identification of immediate response genes dominantly expressed in juvenile resistant and susceptible Biomphalaria glabrata snails upon exposure to Schistosoma mansoni.Molecular and biochemical parasitology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Low-density lipoproteins (LDL) may be important in human schistosomiasis because LDL bound to the surface of the parasite inhibits the binding of anti-schistosomal antibodies. Low-density lipoproteins also may serve as a source of lipids for the parasite membrane synthesis. Here LDL fluorescently labeled with carbocyanine dye (DiI-LDL) was used to measure the specificity of binding of LDL to the surface of schistosomula of Schistosoma mansoni and to examine the distribution of the LDL particles over time. DiI-LDL binding was saturable and specific, with strong inhibition by unlabeled LDL and apoB but not by apoA1, bovine serum albumin, or IgG, and only weak inhibition by high-density lipoproteins. Half of the bound DiI-LDL was displaced by unlabeled LDL. DiI-LDL remained bound on the surface of schistosomula for up to 36 hours in culture. However parasites also ingested both DiI-LDL and a second fluorescent LDL, Bodipy-LDL. Over time, both fluorophores appeared throughout the worm tissues, suggesting the LDL particles were breaking down and that the fluorophores and lipids originally contained within the LDL particle were partitioning throughout the worm. Thus human LDL appears to bind to the surface of schistosomula specifically. Ingested LDL appears to be broken down and may serve as a source of host lipids for the parasite.
Indexed as
Identifiers
2024706PMC1886026W304253520What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.