ArticleVirchows Archiv. A, Pathological anatomy and histopathology1991
Chromogranin A and B in parathyroid tissue of cases of primary hyperparathyroidism: an immunohistochemical study.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 31 citations in OpenAlex.
- Normocalcemic primary hyperparathyroidism in patients with recurrent kidney stones: pathological analysis of parathyroid glands.Virchows Archiv : an international journal of pathology · 2006Article
- Calcitonin immunoreactivity in neoplastic and hyperplastic parathyroid glands: an immunohistochemical study.Endocrine pathology · 2003Article
- Bcl-2, p53 and MIB-1 expression in normal and neoplastic parathyroid tissues.Journal of endocrinological investigation · 1998Article
- Immunohistochemical detection of secretoneurin, a novel neuropeptide endoproteolytically processed from secretogranin II, in normal human endocrine and neuronal tissues.The Histochemical journal · 1995Article
- Immunoreactive Characteristics and Classification of Hyperparathyroidism.Endocrine pathology · 1995Article
- The granin protein family: markers for neuroendocrine cells and tools for the diagnosis of neuroendocrine tumors.Journal of endocrinological investigation · 1994Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
Routinely processed parathyroid tissues from 26 cases with primary hyperparathyroidism (19 adenomas, 7 multiglandular hyperplasia) and 8 normal human parathyroid glands were investigated with antibodies against chromogranin A and B and parathyroid hormone (PTH). Normal parathyroids were immunohistochemically positive for PTH and chromogranin A but negative for chromogranin B. Hyperplastic glands showed a focal staining for PTH and chromogranin A without correlation of the staining pattern on serial sections. Adenomas were either uniformly positive for both PTH and chromogranin A or showed a staining pattern similar to that seen in hyperplastic glands. Focal chromogranin B positivity (less than 10% of cells) was found in 3 cases (1 hyperplastic gland and 2 cases of parathyroid adenoma with an immunohistochemical staining pattern similar to hyperplastic glands). Our immunohistochemical results may support previously published findings that most parathyroid adenomas are monoclonal neoplasms whereas hyperplastic glands are of polyclonal origin.
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