ArticleProceedings of the National Academy of Sciences of the United States of America1991
Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 106 citations in OpenAlex.
- Modulating Vimentin: A Systems-Level Therapeutic Strategy for Sepsis and Complex Diseases.Life (Basel, Switzerland) · 2026Article
- Mechanics of cell sheets: plectin as an integrator of cytoskeletal networks.Open biology · 2025Review
- Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate Cancer.Cancers · 2022Review
- Review
- Review
- Lack of vimentin impairs endothelial differentiation of embryonic stem cells.Scientific reports · 2016Article
- Phosphorylation of serine 4,642 in the C-terminus of plectin by MNK2 and PKA modulates its interaction with intermediate filaments.Journal of cell science · 2013Article
- Plectin-intermediate filament partnership in skin, skeletal muscle, and peripheral nerve.Histochemistry and cell biology · 2013Review
- Partners and post-translational modifications of nuclear lamins.Chromosoma · 2013Review
- Plectin isoforms as organizers of intermediate filament cytoarchitecture.Bioarchitecture · 2011Article
- BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization.Cancer science · 2009Article
- TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.Journal of cell science · 2008Article
- Quantitative phosphoproteome analysis of lysophosphatidic acid induced chemotaxis applying dual-step (18)O labeling coupled with immobilized metal-ion affinity chromatography.Journal of proteome research · 2008Article
- Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia.Biologics : targets & therapy · 2008Article
- Anchoring junctions as drug targets: role in contraceptive development.Pharmacological reviews · 2008Review
- Plectin-like proteins are present in cells of Chlamydomonas eugametos (Volvocales).Folia microbiologica · 2002Article
- Structure and function of a vimentin-associated matrix adhesion in endothelial cells.Molecular biology of the cell · 2001Article
- Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells.The Journal of cell biology · 1999Article
- Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics.The EMBO journal · 1998Article
- Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture.Genes & development · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solid-phase binding assays with protein species purified from cultured rat glioma C6 cells and Ehrlich ascites revealed that plectin bound specifically to lamin B but not to lamins A and C. Lamin B interaction was significantly decreased upon in vitro phosphorylation of either lamin B or plectin with protein kinase A or C. In contrast, phosphorylation of plectin with kinase A increased its binding to vimentin, suggesting a different regulation of plectin interactions by this kinase. 32P-radiolabeling of rat glioma C6 cells revealed plectin as a major in vivo target of protein kinase A and protein kinase C. Plectin, present in lysates of dibutyryladenosine 3',5'-cyclic monophosphate-treated cells, showed a 2.5 times higher binding affinity to vimentin than plectin from phorbol ester-treated cells. Furthermore, the relative amounts of plectin in 1% Triton X-100/high salt-insoluble cell fractions decreased to one-fourth of control values upon treating cells with phorbol esters, whereas vimentin was unaffected. This finding suggested a protein kinase C-dependent weakening of plectin interaction with intermediate filaments in vivo. Taken together, these results point to a role of plectin in interlinking cytoskeletal and nuclear elements and suggest that specific protein kinases are involved in regulating these interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.