ArticleCellular and molecular life sciences : CMLS2010
Accessibility of host cell lineages to medaka stem cells depends on genetic background and irradiation of recipient embryos.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Medaka insulin-like growth factor-2 supports self-renewal of the embryonic stem cell line and blastomeres in vitro.Scientific reports · 2017Article
- Subcellular redistribution and sequential recruitment of macromolecular components during SGIV assembly.Protein & cell · 2016Article
- Germline replacement by blastula cell transplantation in the fish medaka.Scientific reports · 2016Article
- Dazl is a critical player for primordial germ cell formation in medaka.Scientific reports · 2016Article
- Dnd Is a Critical Specifier of Primordial Germ Cells in the Medaka Fish.Stem cell reports · 2016Article
- Autosomal gsdf acts as a male sex initiator in the fish medaka.Scientific reports · 2016Article
- Medaka Oct4 is essential for pluripotency in blastula formation and ES cell derivation.Stem cell reviews and reports · 2015Article
- Gene replacement by zinc finger nucleases in medaka embryos.Marine biotechnology (New York, N.Y.) · 2014Article
- Efficient knockout of transplanted green fluorescent protein gene in medaka using TALENs.Marine biotechnology (New York, N.Y.) · 2014Article
- Derivation and long-term culture of an embryonic stem cell-like line from zebrafish blastomeres under feeder-free condition.Zebrafish · 2014Article
- Parameters and efficiency of direct gene disruption by zinc finger nucleases in medaka embryos.Marine biotechnology (New York, N.Y.) · 2014Article
- Nanos3 gene targeting in medaka ES cells.International journal of biological sciences · 2013Article
- Article
- Efficient detection, quantification and enrichment of subtle allelic alterations.DNA research : an international journal for rapid publication of reports on genes and genomes · 2012Article
- Interordinal chimera formation between medaka and zebrafish for analyzing stem cell differentiation.Stem cells and development · 2012Article
- Sperm nuclear transfer and transgenic production in the fish medaka.International journal of biological sciences · 2011Article
- Medaka tert produces multiple variants with differential expression during differentiation in vitro and in vivo.International journal of biological sciences · 2011Article
- Identification of pluripotency genes in the fish medaka.International journal of biological sciences · 2011Article
- Fish stem cell cultures.International journal of biological sciences · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chimera formation is a powerful tool for analyzing pluripotency in vivo. It has been widely accepted that host cell lineages are generally accessible to embryonic stem (ES) cells with the actual contribution depending solely on the intrinsic pluripotency of transplanted donor cells. Here, we show in the fish medaka (Oryzias latipes) that the host accessibility to ES cell contribution exhibits dramatic differences. Specifically, of three albino host strains tested (i (1) , i (3) and af), only strain i (1) generated pigmented chimeras. Strikingly, this accessibility is completely lost in i (1) but acquired in i (3) after host gamma-irradiation. Host irradiation also differentially affected ES cell contribution to somatic organs and gonad. Therefore, the accessibility of various host cell lineages can vary considerably depending on host strains and cell lineages as well as on irradiation. Our findings underscore the importance of host genotypes for interpreting donor cell pluripotency and for improving ES-derived chimera production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.