ArticleWorld journal of gastroenterology2010
Role of BMP3 in progression of gastric carcinoma in Chinese people.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Multi-gene DNA methylation profiles of tumor suppressor genes for prognostic prediction in gastric cancer.BMC cancer · 2026Article
- Comprehensive Multiomics Analyses Establish the Optimal Prognostic Model for Resectable Gastric Cancer : Prognosis Prediction for Resectable GC.Annals of surgical oncology · 2024Article
- Defining high confidence targets of differential CpG methylation in response to in utero arsenic exposure and implications for cancer risk.Toxicology and applied pharmacology · 2024Article
- Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool.Biomolecules · 2022Review
- BMP3 Affects Cortical and Trabecular Long Bone Development in Mice.International journal of molecular sciences · 2022Article
- BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways.Journal of experimental & clinical cancer research : CR · 2019Article
- 1,25-Dihydroxyvitamin DOncoTargets and therapy · 2019Article
- Methylated Bone Morphogenetic Protein 3 (BMP3) Gene: Evaluation of Tumor Suppressor Function and Biomarker Potential in Biliary Cancer.Journal of molecular biomarkers & diagnosis · 2013Article
- Polymorphisms in bone morphogenetic protein 3 and the risk of papillary thyroid cancer.Oncology letters · 2013Article
- The expression of embryonic liver development genes in hepatitis C induced cirrhosis and hepatocellular carcinoma.Cancers · 2012Article
- Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates.Cancer · 2012Article
- DNA methylation and microRNAs in cancer.World journal of gastroenterology · 2012Review
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relation between gastric cancer and microsatellite instability (MSI), loss of heterozygosity (LOH) and promoter region methylation.
methodsFifty primary gastric carcinoma specimens were collected from patients with no family history of cancer. In addition, normal tissues were also collected from patients as controls. DNA was extracted by polymerase chain reaction for single-strand conformation polymorphism, bisulfite DNA sequencing, and methylation-specific band analysis.
resultsThe positive rate for MSI and LOH in gastric carcinoma was 16% and 20%, respectively. According to the tumor, node and metastasis staging system, the LOH frequency was higher in gastric carcinoma at stages III and IV than in gastric carcinoma at stages I and II (P = 0.01), which was also significantly correlated with lymph node metastasis and clinico- pathological characteristics of gastric carcinoma. Methylation of bone morphogenetic protein 3 (BMP3) gene promoter was detected in 64.44% of gastric carcinoma tissue samples. However, no statistical significance was observed between promoter region methylation and carcinoma differentiation. Interestingly, the BMP3 gene methylation rate was 71.05% and 28.58%, respectively, in MSI positive and negative cases (P = 0.031), suggesting that BMP3 genetic instability and promoter methylation are initiated during gastric carcinogenesis. LOH was detected mostly in the late stages of gastric carcinoma, indicating that gastric carcinoma at late stages has a higher infiltration and a poorer prognosis.
conclusionPromotor region methylation of the BMP3 gene may cause gastric carcinoma in Chinese people.
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