SynthesisThe Cochrane database of systematic reviews2010
Pharmacological treatment of depression in patients with a primary brain tumour.
Synthesis in The Cochrane database of systematic reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 6 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Pharmacological treatment of depression in people with a primary brain tumour.The Cochrane database of systematic reviews · 2020Pooled it
- Depression and glioblastoma, complicated concomitant diseases: a systemic review of published literature.Neurosurgical review · 2020Pooled it
- Antidepressants for the treatment of depression in people with cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Antidepressants for the treatment of depression in people with cancer.The Cochrane database of systematic reviews · 2015Pooled it
- Pharmacological treatment of depression in patients with a primary brain tumour.The Cochrane database of systematic reviews · 2013Pooled it
- [Antidepressants for treatment of depression in palliative patients : a systematic literature review].Schmerz (Berlin, Germany) · 2012Pooled it
- Internet-based guided self-help for glioma patients with depressive symptoms: a randomized controlled trial.Journal of neuro-oncology · 2018Trial
- Internet-based guided self-help for glioma patients with depressive symptoms: design of a randomized controlled trial.BMC neurology · 2014Trial
- A systematic review of pharmacologic treatment efficacy for depression in older patients with cancer.Brain, behavior, & immunity - health · 2022Review
- Paroxetine-Overview of the Molecular Mechanisms of Action.International journal of molecular sciences · 2021Review
- Psychiatric symptoms in glioma patients: from diagnosis to management.Neuropsychiatric disease and treatment · 2015Review
- Symptom management and quality of life in glioma patients.CNS oncology · 2014Review
- Comorbid mental disorders and psychosocial distress in patients with brain tumours and their spouses in the early treatment phase.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with a primary brain tumour often experience depression, for which drug treatment may be prescribed. However, these patients are also at high risk of epileptic seizures, cognitive impairment and fatigue, all of which are potential side-effects of antidepressants. The benefit, or harm, of pharmacological treatment of depression in brain tumour patients is unclear.
objectivesTo assess the benefits and harms of pharmacological treatment of depression in patients with a primary brain tumour. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, Issue 3), MEDLINE (1950 to July 2009) and EMBASE (1980 to July 2009). We searched PsycINFO, the British Nursing Index, LILACS, Psyndex, the NHS National Research Register, the NHS Centre for Reviews and Disseminations' Database of Abstracts of Reviews of Effectiveness (DARE) and Web of Knowledge (covering Science Scisearch, Social Sciences Citation Index and Biological Abstracts) (up to July 2009). We handsearched Neuro-oncology, the Journal of Neuro-oncology, the Journal of Neurology, Neurosurgery and Psychiatry and the Journal of Clinical Oncology (July 1999 to June 2009) and wrote to all the pharmaceutical companies manufacturing antidepressants for use in the UK. SELECTION CRITERIA: We included all randomised controlled trials (RCTs), controlled clinical trials, cohort studies and case-control studies of any pharmacological treatment of depression in patients with a histologically diagnosed primary brain tumour. DATA COLLECTION AND ANALYSIS: No studies met the inclusion criteria for this review. MAIN
resultsWe found no eligible studies evaluating the benefits or harms of any pharmacological treatment of depression in brain tumour patients suffering from depression. AUTHORS'
conclusionsNo high-quality studies have examined the value of any drug treatment of depression in patients with primary brain tumours. Detailed prospective studies and RCTs are needed to inform the safe and effective treatment of this common and important complication of brain tumours.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.